Cargando…

Modulation of Glycoprotein VI and Its Downstream Signaling Pathways as an Antiplatelet Target

Antiplatelet therapy aims to reduce the risk of thrombotic events while maintaining hemostasis. A promising current approach is the inhibition of platelet glycoprotein GPVI-mediated adhesion pathways; pathways that do not involve coagulation. GPVI is a signaling receptor integral for collagen-induce...

Descripción completa

Detalles Bibliográficos
Autor principal:	Fuentes, Eduardo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9456422/ https://www.ncbi.nlm.nih.gov/pubmed/36077280 http://dx.doi.org/10.3390/ijms23179882

Ejemplares similares

Beyond antiplatelets: The role of glycoprotein VI in ischemic stroke
por: Induruwa, Isuru, et al.
Publicado: (2016)

Antiplatelet Activity of Tussilagone via Inhibition of the GPVI Downstream Signaling Pathway in Platelets
por: Zhou, Jing, et al.
Publicado: (2020)

Antiplatelet Activity of Tetramethylpyrazine via Regulation of the P2Y12 Receptor Downstream Signaling Pathway
por: Guan, Baoyi, et al.
Publicado: (2022)

Regulation of Key Antiplatelet Pathways by Bioactive Compounds with Minimal Bleeding Risk
por: Fuentes, Eduardo, et al.
Publicado: (2021)

Glutamate, Glutamate Receptors, and Downstream Signaling Pathways
por: Willard, Stacey S., et al.
Publicado: (2013)

Protein Kinase Cθ Negatively Regulates Store-independent Ca(2+) Entry and Phosphatidylserine Exposure Downstream of Glycoprotein VI in Platelets
por: Harper, Matthew T., et al.
Publicado: (2010)

Oxidative stress and its downstream signaling in aging eyes
por: Pinazo-Durán, María Dolores, et al.
Publicado: (2014)

Roles of AMPK and Its Downstream Signals in Pain Regulation
por: Wang, Shenglan, et al.
Publicado: (2021)

Platelet surface receptor glycoprotein VI-dimer is overexpressed in stroke: The Glycoprotein VI in Stroke (GYPSIE) study results
por: Induruwa, Isuru, et al.
Publicado: (2022)

Signaling Pathways and Downstream Effectors of Host Innate Immunity in Plants
por: Kumar, Jitendra, et al.
Publicado: (2021)

Tissue-specific role and associated downstream signaling pathways of adiponectin
por: Roy, Bipradas, et al.
Publicado: (2021)

Platelet GPVI (Glycoprotein VI) and Thrombotic Complications in the Venous System
por: Perrella, Gina, et al.
Publicado: (2021)

Targeting TRAF3 Downstream Signaling Pathways in B cell Neoplasms
por: Moore, Carissa R, et al.
Publicado: (2015)

Role of heat shock protein 47 in platelet glycoprotein VI dimerization and signaling
por: AlOuda, Sarah K., et al.
Publicado: (2023)

Adenosine Receptor and Its Downstream Targets, Mod(mdg4) and Hsp70, Work as a Signaling Pathway Modulating Cytotoxic Damage in Drosophila
por: Lin, Yu-Hsien, et al.
Publicado: (2021)

EGFR signaling pathway occupies an important position in cancer‐related downstream signaling pathways of Pyk2
por: Shen, Ting, et al.
Publicado: (2019)

Targeting Protein Kinase C Downstream of Growth Factor and Adhesion Signalling
por: Dowling, Catríona M., et al.
Publicado: (2015)

Novel CD44-downstream signaling pathways mediating breast tumor invasion
por: Ouhtit, Allal, et al.
Publicado: (2018)

Glycoprotein VI in securing vascular integrity in inflamed vessels
por: Boulaftali, Yacine, et al.
Publicado: (2018)

Toll-like receptor downstream signaling
por: Kawai, Taro, et al.
Publicado: (2005)

Downstream Signalling from Molecular Hydrogen
por: Hancock, John T., et al.
Publicado: (2021)

RHBDD1 promotes colorectal cancer metastasis through the Wnt signaling pathway and its downstream target ZEB1
por: Zhang, Mengmeng, et al.
Publicado: (2018)

Relationship between Platelet PPARs, cAMP Levels, and P-Selectin Expression: Antiplatelet Activity of Natural Products
por: Fuentes, Eduardo, et al.
Publicado: (2013)

HMGA1 is a novel downstream nuclear target of the insulin receptor signaling pathway
por: Chiefari, Eusebio, et al.
Publicado: (2012)

IRAK3 modulates downstream innate immune signalling through its guanylate cyclase activity
por: Freihat, L. A., et al.
Publicado: (2019)

Rho-Proteins and Downstream Pathways as Potential Targets in Sepsis and Septic Shock: What Have We Learned from Basic Research
por: Hahmeyer, Maria Luísa da Silveira, et al.
Publicado: (2021)

Introduction of an ancient founder glycoprotein VI mutation into the Chilean population
por: Dalby, Amanda, et al.
Publicado: (2022)

Immobilized fibrinogen activates human platelets through glycoprotein VI
por: Mangin, Pierre H, et al.
Publicado: (2018)

Colchicine inhibits ROS generation in response to glycoprotein VI stimulation
por: Pennings, G. J., et al.
Publicado: (2021)

Glenzocimab does not impact glycoprotein VI-dependent inflammatory hemostasis
por: Jadoui, Soumaya, et al.
Publicado: (2020)

Regulation of cGAS Activity and Downstream Signaling
por: Joshi, Bhagwati, et al.
Publicado: (2022)

Correction to: RHBDD1 promotes colorectal cancer metastasis through the Wnt signaling pathway and its downstream target ZEB1
por: Zhang, Mengmeng, et al.
Publicado: (2018)

Modulation of FLT3-ITD Localization and Targeting of Distinct Downstream Signaling Pathways as Potential Strategies to Overcome FLT3-Inhibitor Resistance
por: Fleischmann, Maximilian, et al.
Publicado: (2021)

Serine-71 Phosphorylation of Rac1 Modulates Downstream Signaling
por: Schwarz, Janett, et al.
Publicado: (2012)

Reversing autism by targeting downstream mTOR signaling
por: Wang, Hansen, et al.
Publicado: (2013)

Neem Leaf Glycoprotein Restrains VEGF Production by Direct Modulation of HIF1α-Linked Upstream and Downstream Cascades
por: Saha, Akata, et al.
Publicado: (2020)

Antiplatelet Activity of Natural Bioactive Extracts from Mango (Mangifera Indica L.) and its By-Products
por: Alañón, María Elena, et al.
Publicado: (2019)

Signaling Pathways Leading to mTOR Activation Downstream Cytokine Receptors in Lymphocytes in Health and Disease
por: Fallone, Lucie, et al.
Publicado: (2023)

Ciliary Neurotrophic Factor Modulates Multiple Downstream Signaling Pathways in Prostate Cancer Inhibiting Cell Invasiveness
por: Tossetta, Giovanni, et al.
Publicado: (2022)

G6b-B Inhibits Constitutive and Agonist-induced Signaling by Glycoprotein VI and CLEC-2
por: Mori, Jun, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_531cgag611aro6q1dbbvsd4vlf