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Multiple Cell Cultures for MRI Analysis

Magnetic resonance imaging (MRI) is an imaging method that enables diagnostics. In recent years, this technique has been widely used for research using cell cultures used in pharmaceutical science to understand the distribution of various drugs in a variety of biological samples, from cellular model...

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Detalles Bibliográficos
Autores principales: Bober, Zuzanna, Aebisher, David, Olek, Marcin, Kawczyk-Krupka, Aleksandra, Bartusik-Aebisher, Dorota
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9456466/
https://www.ncbi.nlm.nih.gov/pubmed/36077507
http://dx.doi.org/10.3390/ijms231710109
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author Bober, Zuzanna
Aebisher, David
Olek, Marcin
Kawczyk-Krupka, Aleksandra
Bartusik-Aebisher, Dorota
author_facet Bober, Zuzanna
Aebisher, David
Olek, Marcin
Kawczyk-Krupka, Aleksandra
Bartusik-Aebisher, Dorota
author_sort Bober, Zuzanna
collection PubMed
description Magnetic resonance imaging (MRI) is an imaging method that enables diagnostics. In recent years, this technique has been widely used for research using cell cultures used in pharmaceutical science to understand the distribution of various drugs in a variety of biological samples, from cellular models to tissues. MRI’s dynamic development in recent years, in addition to diagnostics, has allowed the method to be implemented to assess response to applied therapies. Conventional MRI imaging provides anatomical and pathological information. Due to advanced technology, MRI provides physiological information. The use of cell cultures is very important in the process of testing new synthesized drugs, cancer research, and stem cell research, among others. Two-dimensional (2D) cell cultures conducted under laboratory conditions, although they provide a lot of information, do not reflect the basic characteristics of the tumor. To replicate the tumor microenvironment in science, a three-dimensional (3D) culture of tumor cells was developed. This makes it possible to reproduce in vivo conditions where, in addition, there is a complex and dynamic process of cell-to-cell communication and cell–matrix interaction. In this work, we reviewed current research in 2D and 3D cultures and their use in MRI studies. Articles for each section were collected from PubMed, ScienceDirect, Web of Science, and Google Scholar.
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spelling pubmed-94564662022-09-09 Multiple Cell Cultures for MRI Analysis Bober, Zuzanna Aebisher, David Olek, Marcin Kawczyk-Krupka, Aleksandra Bartusik-Aebisher, Dorota Int J Mol Sci Review Magnetic resonance imaging (MRI) is an imaging method that enables diagnostics. In recent years, this technique has been widely used for research using cell cultures used in pharmaceutical science to understand the distribution of various drugs in a variety of biological samples, from cellular models to tissues. MRI’s dynamic development in recent years, in addition to diagnostics, has allowed the method to be implemented to assess response to applied therapies. Conventional MRI imaging provides anatomical and pathological information. Due to advanced technology, MRI provides physiological information. The use of cell cultures is very important in the process of testing new synthesized drugs, cancer research, and stem cell research, among others. Two-dimensional (2D) cell cultures conducted under laboratory conditions, although they provide a lot of information, do not reflect the basic characteristics of the tumor. To replicate the tumor microenvironment in science, a three-dimensional (3D) culture of tumor cells was developed. This makes it possible to reproduce in vivo conditions where, in addition, there is a complex and dynamic process of cell-to-cell communication and cell–matrix interaction. In this work, we reviewed current research in 2D and 3D cultures and their use in MRI studies. Articles for each section were collected from PubMed, ScienceDirect, Web of Science, and Google Scholar. MDPI 2022-09-03 /pmc/articles/PMC9456466/ /pubmed/36077507 http://dx.doi.org/10.3390/ijms231710109 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bober, Zuzanna
Aebisher, David
Olek, Marcin
Kawczyk-Krupka, Aleksandra
Bartusik-Aebisher, Dorota
Multiple Cell Cultures for MRI Analysis
title Multiple Cell Cultures for MRI Analysis
title_full Multiple Cell Cultures for MRI Analysis
title_fullStr Multiple Cell Cultures for MRI Analysis
title_full_unstemmed Multiple Cell Cultures for MRI Analysis
title_short Multiple Cell Cultures for MRI Analysis
title_sort multiple cell cultures for mri analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9456466/
https://www.ncbi.nlm.nih.gov/pubmed/36077507
http://dx.doi.org/10.3390/ijms231710109
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