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Antenatal Glucocorticoid Administration Promotes Cardiac Structure and Energy Metabolism Maturation in Preterm Fetuses

Although the rate of preterm birth has increased in recent decades, a number of preterm infants have escaped death due to improvements in perinatal and neonatal care. Antenatal glucocorticoid (GC) therapy has significantly contributed to progression in lung maturation; however, its potential effects...

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Autores principales: Sakurai, Kenzo, Takeba, Yuko, Osada, Yosuke, Mizuno, Masanori, Tsuzuki, Yoshimitsu, Aso, Kentaro, Kida, Keisuke, Ohta, Yuki, Ootaki, Masanori, Iiri, Taroh, Hokuto, Isamu, Shimizu, Naoki, Matsumoto, Naoki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9456503/
https://www.ncbi.nlm.nih.gov/pubmed/36077580
http://dx.doi.org/10.3390/ijms231710186
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author Sakurai, Kenzo
Takeba, Yuko
Osada, Yosuke
Mizuno, Masanori
Tsuzuki, Yoshimitsu
Aso, Kentaro
Kida, Keisuke
Ohta, Yuki
Ootaki, Masanori
Iiri, Taroh
Hokuto, Isamu
Shimizu, Naoki
Matsumoto, Naoki
author_facet Sakurai, Kenzo
Takeba, Yuko
Osada, Yosuke
Mizuno, Masanori
Tsuzuki, Yoshimitsu
Aso, Kentaro
Kida, Keisuke
Ohta, Yuki
Ootaki, Masanori
Iiri, Taroh
Hokuto, Isamu
Shimizu, Naoki
Matsumoto, Naoki
author_sort Sakurai, Kenzo
collection PubMed
description Although the rate of preterm birth has increased in recent decades, a number of preterm infants have escaped death due to improvements in perinatal and neonatal care. Antenatal glucocorticoid (GC) therapy has significantly contributed to progression in lung maturation; however, its potential effects on other organs remain controversial. Furthermore, the effects of antenatal GC therapy on the fetal heart show both pros and cons. Translational research in animal models indicates that constant fetal exposure to antenatal GC administration is sufficient for lung maturation. We have established a premature fetal rat model to investigate immature cardiopulmonary functions in the lungs and heart, including the effects of antenatal GC administration. In this review, we explain the mechanisms of antenatal GC actions on the heart in the fetus compared to those in the neonate. Antenatal GCs may contribute to premature heart maturation by accelerating cardiomyocyte proliferation, angiogenesis, energy production, and sarcoplasmic reticulum function. Additionally, this review specifically focuses on fetal heart growth with antenatal GC administration in experimental animal models. Moreover, knowledge regarding antenatal GC administration in experimental animal models can be coupled with that from developmental biology, with the potential for the generation of functional cells and tissues that could be used for regenerative medical purposes in the future.
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spelling pubmed-94565032022-09-09 Antenatal Glucocorticoid Administration Promotes Cardiac Structure and Energy Metabolism Maturation in Preterm Fetuses Sakurai, Kenzo Takeba, Yuko Osada, Yosuke Mizuno, Masanori Tsuzuki, Yoshimitsu Aso, Kentaro Kida, Keisuke Ohta, Yuki Ootaki, Masanori Iiri, Taroh Hokuto, Isamu Shimizu, Naoki Matsumoto, Naoki Int J Mol Sci Review Although the rate of preterm birth has increased in recent decades, a number of preterm infants have escaped death due to improvements in perinatal and neonatal care. Antenatal glucocorticoid (GC) therapy has significantly contributed to progression in lung maturation; however, its potential effects on other organs remain controversial. Furthermore, the effects of antenatal GC therapy on the fetal heart show both pros and cons. Translational research in animal models indicates that constant fetal exposure to antenatal GC administration is sufficient for lung maturation. We have established a premature fetal rat model to investigate immature cardiopulmonary functions in the lungs and heart, including the effects of antenatal GC administration. In this review, we explain the mechanisms of antenatal GC actions on the heart in the fetus compared to those in the neonate. Antenatal GCs may contribute to premature heart maturation by accelerating cardiomyocyte proliferation, angiogenesis, energy production, and sarcoplasmic reticulum function. Additionally, this review specifically focuses on fetal heart growth with antenatal GC administration in experimental animal models. Moreover, knowledge regarding antenatal GC administration in experimental animal models can be coupled with that from developmental biology, with the potential for the generation of functional cells and tissues that could be used for regenerative medical purposes in the future. MDPI 2022-09-05 /pmc/articles/PMC9456503/ /pubmed/36077580 http://dx.doi.org/10.3390/ijms231710186 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sakurai, Kenzo
Takeba, Yuko
Osada, Yosuke
Mizuno, Masanori
Tsuzuki, Yoshimitsu
Aso, Kentaro
Kida, Keisuke
Ohta, Yuki
Ootaki, Masanori
Iiri, Taroh
Hokuto, Isamu
Shimizu, Naoki
Matsumoto, Naoki
Antenatal Glucocorticoid Administration Promotes Cardiac Structure and Energy Metabolism Maturation in Preterm Fetuses
title Antenatal Glucocorticoid Administration Promotes Cardiac Structure and Energy Metabolism Maturation in Preterm Fetuses
title_full Antenatal Glucocorticoid Administration Promotes Cardiac Structure and Energy Metabolism Maturation in Preterm Fetuses
title_fullStr Antenatal Glucocorticoid Administration Promotes Cardiac Structure and Energy Metabolism Maturation in Preterm Fetuses
title_full_unstemmed Antenatal Glucocorticoid Administration Promotes Cardiac Structure and Energy Metabolism Maturation in Preterm Fetuses
title_short Antenatal Glucocorticoid Administration Promotes Cardiac Structure and Energy Metabolism Maturation in Preterm Fetuses
title_sort antenatal glucocorticoid administration promotes cardiac structure and energy metabolism maturation in preterm fetuses
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9456503/
https://www.ncbi.nlm.nih.gov/pubmed/36077580
http://dx.doi.org/10.3390/ijms231710186
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