Cargando…
Mass Spectrometric-Based Proteomics for Biomarker Discovery in Osteosarcoma: Current Status and Future Direction
Due to a lack of novel therapies and biomarkers, the clinical outcomes of osteosarcoma patients have not significantly improved for decades. The advancement of mass spectrometry (MS), peptide quantification, and downstream pathway analysis enables the investigation of protein profiles across a wide...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9456544/ https://www.ncbi.nlm.nih.gov/pubmed/36077137 http://dx.doi.org/10.3390/ijms23179741 |
_version_ | 1784785841244078080 |
---|---|
author | Sirikaew, Nutnicha Pruksakorn, Dumnoensun Chaiyawat, Parunya Chutipongtanate, Somchai |
author_facet | Sirikaew, Nutnicha Pruksakorn, Dumnoensun Chaiyawat, Parunya Chutipongtanate, Somchai |
author_sort | Sirikaew, Nutnicha |
collection | PubMed |
description | Due to a lack of novel therapies and biomarkers, the clinical outcomes of osteosarcoma patients have not significantly improved for decades. The advancement of mass spectrometry (MS), peptide quantification, and downstream pathway analysis enables the investigation of protein profiles across a wide range of input materials, from cell culture to long-term archived clinical specimens. This can provide insight into osteosarcoma biology and identify candidate biomarkers for diagnosis, prognosis, and stratification of chemotherapy response. In this review, we provide an overview of proteomics studies of osteosarcoma, indicate potential biomarkers that might be promising therapeutic targets, and discuss the challenges and opportunities of mass spectrometric-based proteomics in future osteosarcoma research. |
format | Online Article Text |
id | pubmed-9456544 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94565442022-09-09 Mass Spectrometric-Based Proteomics for Biomarker Discovery in Osteosarcoma: Current Status and Future Direction Sirikaew, Nutnicha Pruksakorn, Dumnoensun Chaiyawat, Parunya Chutipongtanate, Somchai Int J Mol Sci Review Due to a lack of novel therapies and biomarkers, the clinical outcomes of osteosarcoma patients have not significantly improved for decades. The advancement of mass spectrometry (MS), peptide quantification, and downstream pathway analysis enables the investigation of protein profiles across a wide range of input materials, from cell culture to long-term archived clinical specimens. This can provide insight into osteosarcoma biology and identify candidate biomarkers for diagnosis, prognosis, and stratification of chemotherapy response. In this review, we provide an overview of proteomics studies of osteosarcoma, indicate potential biomarkers that might be promising therapeutic targets, and discuss the challenges and opportunities of mass spectrometric-based proteomics in future osteosarcoma research. MDPI 2022-08-28 /pmc/articles/PMC9456544/ /pubmed/36077137 http://dx.doi.org/10.3390/ijms23179741 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Sirikaew, Nutnicha Pruksakorn, Dumnoensun Chaiyawat, Parunya Chutipongtanate, Somchai Mass Spectrometric-Based Proteomics for Biomarker Discovery in Osteosarcoma: Current Status and Future Direction |
title | Mass Spectrometric-Based Proteomics for Biomarker Discovery in Osteosarcoma: Current Status and Future Direction |
title_full | Mass Spectrometric-Based Proteomics for Biomarker Discovery in Osteosarcoma: Current Status and Future Direction |
title_fullStr | Mass Spectrometric-Based Proteomics for Biomarker Discovery in Osteosarcoma: Current Status and Future Direction |
title_full_unstemmed | Mass Spectrometric-Based Proteomics for Biomarker Discovery in Osteosarcoma: Current Status and Future Direction |
title_short | Mass Spectrometric-Based Proteomics for Biomarker Discovery in Osteosarcoma: Current Status and Future Direction |
title_sort | mass spectrometric-based proteomics for biomarker discovery in osteosarcoma: current status and future direction |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9456544/ https://www.ncbi.nlm.nih.gov/pubmed/36077137 http://dx.doi.org/10.3390/ijms23179741 |
work_keys_str_mv | AT sirikaewnutnicha massspectrometricbasedproteomicsforbiomarkerdiscoveryinosteosarcomacurrentstatusandfuturedirection AT pruksakorndumnoensun massspectrometricbasedproteomicsforbiomarkerdiscoveryinosteosarcomacurrentstatusandfuturedirection AT chaiyawatparunya massspectrometricbasedproteomicsforbiomarkerdiscoveryinosteosarcomacurrentstatusandfuturedirection AT chutipongtanatesomchai massspectrometricbasedproteomicsforbiomarkerdiscoveryinosteosarcomacurrentstatusandfuturedirection |