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Evaluation of the Anti-Atopic Dermatitis Effects of α-Boswellic Acid on Tnf-α/Ifn-γ-Stimulated HaCat Cells and DNCB-Induced BALB/c Mice

Boswellic acids, triterpenoids derived from the genus Boswellia (Burseraceae), are known for their anti-inflammatory and anti-tumor efficacy. Atopic dermatitis is a chronic, non-infectious inflammatory skin disease. However, the effects of α-boswellic acid on atopic dermatitis have not been studied....

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Autores principales: Tsai, Ya-Chu, Chang, Hsun-Hao, Chou, Sheng-Chieh, Chu, Thomas W., Hsu, Yu-Jou, Hsiao, Chien-Yu, Lo, Yuan-Hsin, Wu, Nan-Lin, Chang, Der-Chen, Hung, Chi-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9456567/
https://www.ncbi.nlm.nih.gov/pubmed/36077254
http://dx.doi.org/10.3390/ijms23179863
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author Tsai, Ya-Chu
Chang, Hsun-Hao
Chou, Sheng-Chieh
Chu, Thomas W.
Hsu, Yu-Jou
Hsiao, Chien-Yu
Lo, Yuan-Hsin
Wu, Nan-Lin
Chang, Der-Chen
Hung, Chi-Feng
author_facet Tsai, Ya-Chu
Chang, Hsun-Hao
Chou, Sheng-Chieh
Chu, Thomas W.
Hsu, Yu-Jou
Hsiao, Chien-Yu
Lo, Yuan-Hsin
Wu, Nan-Lin
Chang, Der-Chen
Hung, Chi-Feng
author_sort Tsai, Ya-Chu
collection PubMed
description Boswellic acids, triterpenoids derived from the genus Boswellia (Burseraceae), are known for their anti-inflammatory and anti-tumor efficacy. Atopic dermatitis is a chronic, non-infectious inflammatory skin disease. However, the effects of α-boswellic acid on atopic dermatitis have not been studied. Therefore, in this study we examined the expression level of pro-inflammatory cytokines, histopathological analysis, and physiological data from BALB/c mice with atopic-like dermatitis induced by 2,4-dinitrochlorobenzene and TNF-α/IFN-γ-stimulated HaCaT cells to better understand the agent’s anti-atopic dermatitis efficacy. First, we found that α-boswellic reduced the epidermal thickening, mast cell numbers, and dermal infiltration of 2,4-dinitrochlorobenzene-induced atopic-like dermatitis in BALB/c mice. Furthermore, we also found that α-boswellic acid can restore transepidermal water loss and skin reddening in mice. In human keratinocytes inflamed by TNF-α/IFN-γ, α-boswellic acid inhibited MAP kinase activation and showed a reduction in NF-κB nuclear translocation. Finally, α-boswellic acid can reduce the expression level of cytokines (IL-1β, IL-6, and IL-8) following the stimulation of TNF-α/IFN-γ in HaCaT cells. Taken together, our study suggests that α-boswellic acids are a potential component for the development of anti-atopic dermatitis drugs.
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spelling pubmed-94565672022-09-09 Evaluation of the Anti-Atopic Dermatitis Effects of α-Boswellic Acid on Tnf-α/Ifn-γ-Stimulated HaCat Cells and DNCB-Induced BALB/c Mice Tsai, Ya-Chu Chang, Hsun-Hao Chou, Sheng-Chieh Chu, Thomas W. Hsu, Yu-Jou Hsiao, Chien-Yu Lo, Yuan-Hsin Wu, Nan-Lin Chang, Der-Chen Hung, Chi-Feng Int J Mol Sci Article Boswellic acids, triterpenoids derived from the genus Boswellia (Burseraceae), are known for their anti-inflammatory and anti-tumor efficacy. Atopic dermatitis is a chronic, non-infectious inflammatory skin disease. However, the effects of α-boswellic acid on atopic dermatitis have not been studied. Therefore, in this study we examined the expression level of pro-inflammatory cytokines, histopathological analysis, and physiological data from BALB/c mice with atopic-like dermatitis induced by 2,4-dinitrochlorobenzene and TNF-α/IFN-γ-stimulated HaCaT cells to better understand the agent’s anti-atopic dermatitis efficacy. First, we found that α-boswellic reduced the epidermal thickening, mast cell numbers, and dermal infiltration of 2,4-dinitrochlorobenzene-induced atopic-like dermatitis in BALB/c mice. Furthermore, we also found that α-boswellic acid can restore transepidermal water loss and skin reddening in mice. In human keratinocytes inflamed by TNF-α/IFN-γ, α-boswellic acid inhibited MAP kinase activation and showed a reduction in NF-κB nuclear translocation. Finally, α-boswellic acid can reduce the expression level of cytokines (IL-1β, IL-6, and IL-8) following the stimulation of TNF-α/IFN-γ in HaCaT cells. Taken together, our study suggests that α-boswellic acids are a potential component for the development of anti-atopic dermatitis drugs. MDPI 2022-08-30 /pmc/articles/PMC9456567/ /pubmed/36077254 http://dx.doi.org/10.3390/ijms23179863 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tsai, Ya-Chu
Chang, Hsun-Hao
Chou, Sheng-Chieh
Chu, Thomas W.
Hsu, Yu-Jou
Hsiao, Chien-Yu
Lo, Yuan-Hsin
Wu, Nan-Lin
Chang, Der-Chen
Hung, Chi-Feng
Evaluation of the Anti-Atopic Dermatitis Effects of α-Boswellic Acid on Tnf-α/Ifn-γ-Stimulated HaCat Cells and DNCB-Induced BALB/c Mice
title Evaluation of the Anti-Atopic Dermatitis Effects of α-Boswellic Acid on Tnf-α/Ifn-γ-Stimulated HaCat Cells and DNCB-Induced BALB/c Mice
title_full Evaluation of the Anti-Atopic Dermatitis Effects of α-Boswellic Acid on Tnf-α/Ifn-γ-Stimulated HaCat Cells and DNCB-Induced BALB/c Mice
title_fullStr Evaluation of the Anti-Atopic Dermatitis Effects of α-Boswellic Acid on Tnf-α/Ifn-γ-Stimulated HaCat Cells and DNCB-Induced BALB/c Mice
title_full_unstemmed Evaluation of the Anti-Atopic Dermatitis Effects of α-Boswellic Acid on Tnf-α/Ifn-γ-Stimulated HaCat Cells and DNCB-Induced BALB/c Mice
title_short Evaluation of the Anti-Atopic Dermatitis Effects of α-Boswellic Acid on Tnf-α/Ifn-γ-Stimulated HaCat Cells and DNCB-Induced BALB/c Mice
title_sort evaluation of the anti-atopic dermatitis effects of α-boswellic acid on tnf-α/ifn-γ-stimulated hacat cells and dncb-induced balb/c mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9456567/
https://www.ncbi.nlm.nih.gov/pubmed/36077254
http://dx.doi.org/10.3390/ijms23179863
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