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Hepatitis C Infection as a Risk Factor for Hypertension and Cardiovascular Diseases: An EpiTer Multicenter Study

Hepatitis C infection is one of the main reasons for liver cirrhosis and hepatocellular carcinoma. In recent years, more and more is being heard about extrahepatic manifestations of the hepatitis C infection including its possible influence on the development of hypertension and cardiovascular disea...

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Autores principales: Rajewski, Paweł, Zarębska-Michaluk, Dorota, Janczewska, Ewa, Gietka, Andrzej, Mazur, Włodzimierz, Tudrujek-Zdunek, Magdalena, Tomasiewicz, Krzysztof, Belica-Wdowik, Teresa, Baka-Ćwierz, Barbara, Dybowska, Dorota, Halota, Waldemar, Lorenc, Beata, Sitko, Marek, Garlicki, Aleksander, Berak, Hanna, Horban, Andrzej, Orłowska, Iwona, Simon, Krzysztof, Socha, Łukasz, Wawrzynowicz-Syczewska, Marta, Jaroszewicz, Jerzy, Deroń, Zbigniew, Czauż-Andrzejuk, Agnieszka, Citko, Jolanta, Krygier, Rafał, Piekarska, Anna, Laurans, Łukasz, Dobracki, Witold, Białkowska, Jolanta, Tronina, Olga, Wietlicka-Piszcz, Magdalena, Pawłowska, Małgorzata, Flisiak, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9456581/
https://www.ncbi.nlm.nih.gov/pubmed/36079122
http://dx.doi.org/10.3390/jcm11175193
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author Rajewski, Paweł
Zarębska-Michaluk, Dorota
Janczewska, Ewa
Gietka, Andrzej
Mazur, Włodzimierz
Tudrujek-Zdunek, Magdalena
Tomasiewicz, Krzysztof
Belica-Wdowik, Teresa
Baka-Ćwierz, Barbara
Dybowska, Dorota
Halota, Waldemar
Lorenc, Beata
Sitko, Marek
Garlicki, Aleksander
Berak, Hanna
Horban, Andrzej
Orłowska, Iwona
Simon, Krzysztof
Socha, Łukasz
Wawrzynowicz-Syczewska, Marta
Jaroszewicz, Jerzy
Deroń, Zbigniew
Czauż-Andrzejuk, Agnieszka
Citko, Jolanta
Krygier, Rafał
Piekarska, Anna
Laurans, Łukasz
Dobracki, Witold
Białkowska, Jolanta
Tronina, Olga
Wietlicka-Piszcz, Magdalena
Pawłowska, Małgorzata
Flisiak, Robert
author_facet Rajewski, Paweł
Zarębska-Michaluk, Dorota
Janczewska, Ewa
Gietka, Andrzej
Mazur, Włodzimierz
Tudrujek-Zdunek, Magdalena
Tomasiewicz, Krzysztof
Belica-Wdowik, Teresa
Baka-Ćwierz, Barbara
Dybowska, Dorota
Halota, Waldemar
Lorenc, Beata
Sitko, Marek
Garlicki, Aleksander
Berak, Hanna
Horban, Andrzej
Orłowska, Iwona
Simon, Krzysztof
Socha, Łukasz
Wawrzynowicz-Syczewska, Marta
Jaroszewicz, Jerzy
Deroń, Zbigniew
Czauż-Andrzejuk, Agnieszka
Citko, Jolanta
Krygier, Rafał
Piekarska, Anna
Laurans, Łukasz
Dobracki, Witold
Białkowska, Jolanta
Tronina, Olga
Wietlicka-Piszcz, Magdalena
Pawłowska, Małgorzata
Flisiak, Robert
author_sort Rajewski, Paweł
collection PubMed
description Hepatitis C infection is one of the main reasons for liver cirrhosis and hepatocellular carcinoma. In recent years, more and more is being heard about extrahepatic manifestations of the hepatitis C infection including its possible influence on the development of hypertension and cardiovascular diseases. In the given work, the frequency analysis of the incidence of hypertension and cardiovascular diseases among 2898 HCV-infected patients treated in Poland and the assessment of their relevance to the HCV genotype and the progression of liver fibrosis can be found. The prevalence of hypertension in the group of analyzed patients was 39% and was significantly associated with old age (OR = 1.08 (1.07–1.08)) and female sex, as well as the progression of liver fibrosis (OR = 1.54 (1.29–1.85)). Hypertension was found in 47.6% of patients with F4 fibrosis, 42.1% of patients with F3 fibrosis, and 25% of patients with F1 fibrosis. The incidence of cardiovascular disease in the studied group of patients was as follows: all incidents, 131 (4.52%); including ischemic heart disease 104, (3.95%); stroke, 2 (0.07%); atherosclerosis, 21 (0.72%); and aneurysms, 4 (0.14%). The obtained results prove that the prevalence of cardiovascular diseases is significantly associated with the advanced age of patients and the progression of liver fibrosis. The relevance of sex and the HCV genotype to the prevalence frequency of cardiovascular diseases in the study group has not been proven. This being the case, no differences in the frequency of their incidence depending on the HCV genotype, including genotype 3, was found. Hepatitis C infection as a non-classical risk factor for cardiovascular disease and hypertension does require further studying.
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spelling pubmed-94565812022-09-09 Hepatitis C Infection as a Risk Factor for Hypertension and Cardiovascular Diseases: An EpiTer Multicenter Study Rajewski, Paweł Zarębska-Michaluk, Dorota Janczewska, Ewa Gietka, Andrzej Mazur, Włodzimierz Tudrujek-Zdunek, Magdalena Tomasiewicz, Krzysztof Belica-Wdowik, Teresa Baka-Ćwierz, Barbara Dybowska, Dorota Halota, Waldemar Lorenc, Beata Sitko, Marek Garlicki, Aleksander Berak, Hanna Horban, Andrzej Orłowska, Iwona Simon, Krzysztof Socha, Łukasz Wawrzynowicz-Syczewska, Marta Jaroszewicz, Jerzy Deroń, Zbigniew Czauż-Andrzejuk, Agnieszka Citko, Jolanta Krygier, Rafał Piekarska, Anna Laurans, Łukasz Dobracki, Witold Białkowska, Jolanta Tronina, Olga Wietlicka-Piszcz, Magdalena Pawłowska, Małgorzata Flisiak, Robert J Clin Med Article Hepatitis C infection is one of the main reasons for liver cirrhosis and hepatocellular carcinoma. In recent years, more and more is being heard about extrahepatic manifestations of the hepatitis C infection including its possible influence on the development of hypertension and cardiovascular diseases. In the given work, the frequency analysis of the incidence of hypertension and cardiovascular diseases among 2898 HCV-infected patients treated in Poland and the assessment of their relevance to the HCV genotype and the progression of liver fibrosis can be found. The prevalence of hypertension in the group of analyzed patients was 39% and was significantly associated with old age (OR = 1.08 (1.07–1.08)) and female sex, as well as the progression of liver fibrosis (OR = 1.54 (1.29–1.85)). Hypertension was found in 47.6% of patients with F4 fibrosis, 42.1% of patients with F3 fibrosis, and 25% of patients with F1 fibrosis. The incidence of cardiovascular disease in the studied group of patients was as follows: all incidents, 131 (4.52%); including ischemic heart disease 104, (3.95%); stroke, 2 (0.07%); atherosclerosis, 21 (0.72%); and aneurysms, 4 (0.14%). The obtained results prove that the prevalence of cardiovascular diseases is significantly associated with the advanced age of patients and the progression of liver fibrosis. The relevance of sex and the HCV genotype to the prevalence frequency of cardiovascular diseases in the study group has not been proven. This being the case, no differences in the frequency of their incidence depending on the HCV genotype, including genotype 3, was found. Hepatitis C infection as a non-classical risk factor for cardiovascular disease and hypertension does require further studying. MDPI 2022-09-01 /pmc/articles/PMC9456581/ /pubmed/36079122 http://dx.doi.org/10.3390/jcm11175193 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rajewski, Paweł
Zarębska-Michaluk, Dorota
Janczewska, Ewa
Gietka, Andrzej
Mazur, Włodzimierz
Tudrujek-Zdunek, Magdalena
Tomasiewicz, Krzysztof
Belica-Wdowik, Teresa
Baka-Ćwierz, Barbara
Dybowska, Dorota
Halota, Waldemar
Lorenc, Beata
Sitko, Marek
Garlicki, Aleksander
Berak, Hanna
Horban, Andrzej
Orłowska, Iwona
Simon, Krzysztof
Socha, Łukasz
Wawrzynowicz-Syczewska, Marta
Jaroszewicz, Jerzy
Deroń, Zbigniew
Czauż-Andrzejuk, Agnieszka
Citko, Jolanta
Krygier, Rafał
Piekarska, Anna
Laurans, Łukasz
Dobracki, Witold
Białkowska, Jolanta
Tronina, Olga
Wietlicka-Piszcz, Magdalena
Pawłowska, Małgorzata
Flisiak, Robert
Hepatitis C Infection as a Risk Factor for Hypertension and Cardiovascular Diseases: An EpiTer Multicenter Study
title Hepatitis C Infection as a Risk Factor for Hypertension and Cardiovascular Diseases: An EpiTer Multicenter Study
title_full Hepatitis C Infection as a Risk Factor for Hypertension and Cardiovascular Diseases: An EpiTer Multicenter Study
title_fullStr Hepatitis C Infection as a Risk Factor for Hypertension and Cardiovascular Diseases: An EpiTer Multicenter Study
title_full_unstemmed Hepatitis C Infection as a Risk Factor for Hypertension and Cardiovascular Diseases: An EpiTer Multicenter Study
title_short Hepatitis C Infection as a Risk Factor for Hypertension and Cardiovascular Diseases: An EpiTer Multicenter Study
title_sort hepatitis c infection as a risk factor for hypertension and cardiovascular diseases: an epiter multicenter study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9456581/
https://www.ncbi.nlm.nih.gov/pubmed/36079122
http://dx.doi.org/10.3390/jcm11175193
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