A Novel Method to Combine Maxilla-Based Coordinate System and Mandibular Voxel-Based Superimposition with Cone-Bean Computed Tomography

Background: The objective of this study was to propose a method that combines a maxilla-based coordinate system and mandibular voxel-based superimposition for an accurate evaluation of mandibular structural and positional changes and a direct comparison between maxillary and mandibular structural changes with the same 3D vectors. Methods: Mandibular voxel-based superimposition was firstly performed to reorient the mandibles and eliminate the mandibular positional changes. Then, a maxilla-based coordinate system was constructed with four maxillary skeletal landmarks (ANS, PNS, OrL and OrR). After settling the reoriented mandibles into this coordinate system, the mandibular structural changes were accurately evaluated. To assess the accuracy and reproducibility of this method, CBCT images of a skull specimen before and after orthodontic treatment (which was simulated by rearranging the skull and the mandible) were collected. Five mandibular skeletal landmarks, three mandibular dental landmarks and two mandibular measurement planes of this skull were used to evaluate the linear and angular changes in the mandibular structures. Results: There were significant differences in the linear and angular measurements of the mandibular structures of the skull (p ˂ 0.05), which indicated mandibular positional changes after orthodontic treatment. After mandibular voxel-based superimposition, there were no significant differences in the linear and angular measurements of mandibular structures, which indicated that the mandibular positional changes were eliminated. The intraclass correlation coefficient (ICC) value of the inter- and intra-observer agreement of all measurements was 0.99. Conclusions: This method has proven advantages in terms of accuracy, reproducibility and validity; with this method, mandibular structural and positional changes can be accurately evaluated and maxillary and mandibular structural changes can be directly compared with same 3D vectors.