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Interaction Effects of Maternal Sexually Transmitted Infections with Prenatal Care Utilization Status on Preterm Birth and Low Birthweight: U.S. National Data

This case-control study aimed to test interaction between the most common sexually transmitted infections (STIs) (i.e., chlamydia, gonorrhea, and syphilis) and prenatal care (PNC) utilization status on preterm birth (PTB) (<37 weeks gestation) and low birthweight (LBW) (<2500 g). We used data...

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Autores principales: Kondracki, Anthony J., Li, Wei, Bursac, Zoran, Mokhtari, Manouchehr, Reddick, Bonzo, Barkin, Jennifer L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9456665/
https://www.ncbi.nlm.nih.gov/pubmed/36079115
http://dx.doi.org/10.3390/jcm11175184
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author Kondracki, Anthony J.
Li, Wei
Bursac, Zoran
Mokhtari, Manouchehr
Reddick, Bonzo
Barkin, Jennifer L.
author_facet Kondracki, Anthony J.
Li, Wei
Bursac, Zoran
Mokhtari, Manouchehr
Reddick, Bonzo
Barkin, Jennifer L.
author_sort Kondracki, Anthony J.
collection PubMed
description This case-control study aimed to test interaction between the most common sexually transmitted infections (STIs) (i.e., chlamydia, gonorrhea, and syphilis) and prenatal care (PNC) utilization status on preterm birth (PTB) (<37 weeks gestation) and low birthweight (LBW) (<2500 g). We used data of participants with singleton live births (N = 3,418,028) from the 2019 United States National Vital Statistics System. There were 280,206 participants in the PTB group and 3,137,822 in the control group, and 221,260 participants in the LBW group and 3,196,768 in the control group. Nearly 1.9% of the participants had chlamydia, 0.3% had gonorrhea, and 0.2% had syphilis. Interaction effects of STIs with PNC utilization status on the risk of PTB and LBW were tested on the multiplicative and additive scales. Using measures of the relative excess risk of interaction (RERI), the attributable proportion of interaction (AP), and the synergy index (S), we observed the highest significant synergistic interaction between syphilis and inadequate PNC utilization increasing the risk of PTB (RERI 2.12, AP 38%, and SI 1.88), and between gonorrhea and inadequate PNC utilization increasing the risk of LBW (RERI 1.03, AP 28%, and SI 1.64). Findings from this study help improve our understanding of disease etiology and inform prevention planning.
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spelling pubmed-94566652022-09-09 Interaction Effects of Maternal Sexually Transmitted Infections with Prenatal Care Utilization Status on Preterm Birth and Low Birthweight: U.S. National Data Kondracki, Anthony J. Li, Wei Bursac, Zoran Mokhtari, Manouchehr Reddick, Bonzo Barkin, Jennifer L. J Clin Med Article This case-control study aimed to test interaction between the most common sexually transmitted infections (STIs) (i.e., chlamydia, gonorrhea, and syphilis) and prenatal care (PNC) utilization status on preterm birth (PTB) (<37 weeks gestation) and low birthweight (LBW) (<2500 g). We used data of participants with singleton live births (N = 3,418,028) from the 2019 United States National Vital Statistics System. There were 280,206 participants in the PTB group and 3,137,822 in the control group, and 221,260 participants in the LBW group and 3,196,768 in the control group. Nearly 1.9% of the participants had chlamydia, 0.3% had gonorrhea, and 0.2% had syphilis. Interaction effects of STIs with PNC utilization status on the risk of PTB and LBW were tested on the multiplicative and additive scales. Using measures of the relative excess risk of interaction (RERI), the attributable proportion of interaction (AP), and the synergy index (S), we observed the highest significant synergistic interaction between syphilis and inadequate PNC utilization increasing the risk of PTB (RERI 2.12, AP 38%, and SI 1.88), and between gonorrhea and inadequate PNC utilization increasing the risk of LBW (RERI 1.03, AP 28%, and SI 1.64). Findings from this study help improve our understanding of disease etiology and inform prevention planning. MDPI 2022-09-01 /pmc/articles/PMC9456665/ /pubmed/36079115 http://dx.doi.org/10.3390/jcm11175184 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kondracki, Anthony J.
Li, Wei
Bursac, Zoran
Mokhtari, Manouchehr
Reddick, Bonzo
Barkin, Jennifer L.
Interaction Effects of Maternal Sexually Transmitted Infections with Prenatal Care Utilization Status on Preterm Birth and Low Birthweight: U.S. National Data
title Interaction Effects of Maternal Sexually Transmitted Infections with Prenatal Care Utilization Status on Preterm Birth and Low Birthweight: U.S. National Data
title_full Interaction Effects of Maternal Sexually Transmitted Infections with Prenatal Care Utilization Status on Preterm Birth and Low Birthweight: U.S. National Data
title_fullStr Interaction Effects of Maternal Sexually Transmitted Infections with Prenatal Care Utilization Status on Preterm Birth and Low Birthweight: U.S. National Data
title_full_unstemmed Interaction Effects of Maternal Sexually Transmitted Infections with Prenatal Care Utilization Status on Preterm Birth and Low Birthweight: U.S. National Data
title_short Interaction Effects of Maternal Sexually Transmitted Infections with Prenatal Care Utilization Status on Preterm Birth and Low Birthweight: U.S. National Data
title_sort interaction effects of maternal sexually transmitted infections with prenatal care utilization status on preterm birth and low birthweight: u.s. national data
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9456665/
https://www.ncbi.nlm.nih.gov/pubmed/36079115
http://dx.doi.org/10.3390/jcm11175184
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