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Adaptive exchange sustains cullin–RING ubiquitin ligase networks and proper licensing of DNA replication

Cop9 signalosome (CSN) regulates the function of cullin–RING E3 ubiquitin ligases (CRLs) by deconjugating the ubiquitin-like protein NEDD8 from the cullin subunit. To understand the physiological impact of CSN function on the CRL network and cell proliferation, we combined quantitative mass spectrom...

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Detalles Bibliográficos
Autores principales:	Zhang, Yaru, Jost, Marco, Pak, Ryan A., Lu, Daniel, Li, Jing, Lomenick, Brett, Garbis, Spiros D., Li, Chi-Ming, Weissman, Jonathan S., Lipford, James Russell, Deshaies, Raymond J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9456757/ https://www.ncbi.nlm.nih.gov/pubmed/36037385 http://dx.doi.org/10.1073/pnas.2205608119

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