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Disruption of mitochondria–sarcoplasmic reticulum microdomain connectomics contributes to sinus node dysfunction in heart failure

The sinoatrial node (SAN), the leading pacemaker region, generates electrical impulses that propagate throughout the heart. SAN dysfunction with bradyarrhythmia is well documented in heart failure (HF). However, the underlying mechanisms are not completely understood. Mitochondria are critical to ce...

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Detalles Bibliográficos
Autores principales:	Ren, Lu, Gopireddy, Raghavender R., Perkins, Guy, Zhang, Hao, Timofeyev, Valeriy, Lyu, Yankun, Diloretto, Daphne A., Trinh, Pauline, Sirish, Padmini, Overton, James L., Xu, Wilson, Grainger, Nathan, Xiang, Yang K., Dedkova, Elena N., Zhang, Xiao-Dong, Yamoah, Ebenezer N., Navedo, Manuel F., Thai, Phung N., Chiamvimonvat, Nipavan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9456763/ https://www.ncbi.nlm.nih.gov/pubmed/36044551 http://dx.doi.org/10.1073/pnas.2206708119

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