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Analysis of Mortality in Unvaccinated Patients with COVID-19 and Cardiovascular Risk

COVID-19 is a contagious disease that has spread globally, killing millions of people around the world. In order to reduce the likelihood of in-hospital death due to COVID-19, it is reasonable to select a group of patients with a low probability of survival and to implement measures in advance to mi...

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Autores principales: Sarzyńska, Kathie, Świątkowski, Filip, Janc, Jarosław, Zabierowski, Jan, Jankowska-Polańska, Beata, Chabowski, Mariusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9456782/
https://www.ncbi.nlm.nih.gov/pubmed/36078933
http://dx.doi.org/10.3390/jcm11175004
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author Sarzyńska, Kathie
Świątkowski, Filip
Janc, Jarosław
Zabierowski, Jan
Jankowska-Polańska, Beata
Chabowski, Mariusz
author_facet Sarzyńska, Kathie
Świątkowski, Filip
Janc, Jarosław
Zabierowski, Jan
Jankowska-Polańska, Beata
Chabowski, Mariusz
author_sort Sarzyńska, Kathie
collection PubMed
description COVID-19 is a contagious disease that has spread globally, killing millions of people around the world. In order to reduce the likelihood of in-hospital death due to COVID-19, it is reasonable to select a group of patients with a low probability of survival and to implement measures in advance to minimize the risk of death. One way to do this is to establish cut-off values for the most commonly performed blood laboratory tests, above or below which the likelihood of death increases significantly. The aim of the study was to determine the basic laboratory parameters among unvaccinated patients hospitalized for COVID-19 with concomitant cardiovascular disease, which are the predictors of in-hospital death. Out of 1234 patients, 446 people who met the specific inclusion criteria were enrolled in the study. The multivariate regression analysis has shown that the independent predictors of death are: troponin levels of at least 0.033 μg/L (OR = 2.04 [1.10; 3.79]), creatinine of at least 1.88 mg/dL (OR = 2.88 [1.57; 5.30]), D-dimers of at least 0.97 g/L (OR = 2.04 [1.02; 4.07]), and C-reactive protein minimum of 0.89 mg/L (OR = 2.28 [1.24; 4.18]).
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spelling pubmed-94567822022-09-09 Analysis of Mortality in Unvaccinated Patients with COVID-19 and Cardiovascular Risk Sarzyńska, Kathie Świątkowski, Filip Janc, Jarosław Zabierowski, Jan Jankowska-Polańska, Beata Chabowski, Mariusz J Clin Med Article COVID-19 is a contagious disease that has spread globally, killing millions of people around the world. In order to reduce the likelihood of in-hospital death due to COVID-19, it is reasonable to select a group of patients with a low probability of survival and to implement measures in advance to minimize the risk of death. One way to do this is to establish cut-off values for the most commonly performed blood laboratory tests, above or below which the likelihood of death increases significantly. The aim of the study was to determine the basic laboratory parameters among unvaccinated patients hospitalized for COVID-19 with concomitant cardiovascular disease, which are the predictors of in-hospital death. Out of 1234 patients, 446 people who met the specific inclusion criteria were enrolled in the study. The multivariate regression analysis has shown that the independent predictors of death are: troponin levels of at least 0.033 μg/L (OR = 2.04 [1.10; 3.79]), creatinine of at least 1.88 mg/dL (OR = 2.88 [1.57; 5.30]), D-dimers of at least 0.97 g/L (OR = 2.04 [1.02; 4.07]), and C-reactive protein minimum of 0.89 mg/L (OR = 2.28 [1.24; 4.18]). MDPI 2022-08-26 /pmc/articles/PMC9456782/ /pubmed/36078933 http://dx.doi.org/10.3390/jcm11175004 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sarzyńska, Kathie
Świątkowski, Filip
Janc, Jarosław
Zabierowski, Jan
Jankowska-Polańska, Beata
Chabowski, Mariusz
Analysis of Mortality in Unvaccinated Patients with COVID-19 and Cardiovascular Risk
title Analysis of Mortality in Unvaccinated Patients with COVID-19 and Cardiovascular Risk
title_full Analysis of Mortality in Unvaccinated Patients with COVID-19 and Cardiovascular Risk
title_fullStr Analysis of Mortality in Unvaccinated Patients with COVID-19 and Cardiovascular Risk
title_full_unstemmed Analysis of Mortality in Unvaccinated Patients with COVID-19 and Cardiovascular Risk
title_short Analysis of Mortality in Unvaccinated Patients with COVID-19 and Cardiovascular Risk
title_sort analysis of mortality in unvaccinated patients with covid-19 and cardiovascular risk
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9456782/
https://www.ncbi.nlm.nih.gov/pubmed/36078933
http://dx.doi.org/10.3390/jcm11175004
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