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Systematic Review of Risk Factors Assessed in Predictive Scoring Tools for Drug-Related Problems in Inpatients

Drug-related problems (DRP, defined as adverse drug events/reactions and medication errors) are a common threat for patient safety. With the aim to aid improved allocation of specialist resources and to improve detection and prevention of DRP, numerous predictive scoring tools have been proposed. Th...

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Autores principales: Jung-Poppe, Lea, Nicolaus, Hagen Fabian, Roggenhofer, Anna, Altenbuchner, Anna, Dormann, Harald, Pfistermeister, Barbara, Maas, Renke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9457151/
https://www.ncbi.nlm.nih.gov/pubmed/36079114
http://dx.doi.org/10.3390/jcm11175185
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author Jung-Poppe, Lea
Nicolaus, Hagen Fabian
Roggenhofer, Anna
Altenbuchner, Anna
Dormann, Harald
Pfistermeister, Barbara
Maas, Renke
author_facet Jung-Poppe, Lea
Nicolaus, Hagen Fabian
Roggenhofer, Anna
Altenbuchner, Anna
Dormann, Harald
Pfistermeister, Barbara
Maas, Renke
author_sort Jung-Poppe, Lea
collection PubMed
description Drug-related problems (DRP, defined as adverse drug events/reactions and medication errors) are a common threat for patient safety. With the aim to aid improved allocation of specialist resources and to improve detection and prevention of DRP, numerous predictive scoring tools have been proposed. The external validation and evidence for the transferability of these tools still faces limitations. However, the proposed scoring tools include partly overlapping sets of similar factors, which may allow a new approach to estimate the external usability and validity of individual risk factors. Therefore, we conducted this systematic review and analysis. We identified 14 key studies that assessed 844 candidate risk factors for inclusion into predictive scoring tools. After consolidation to account for overlapping terminology and variable definitions, we assessed each risk factor in the number of studies it was assessed, and, if it was found to be a significant predictor of DRP, whether it was included in a final scoring tool. The latter included intake of ≥ 8 drugs, drugs of the Anatomical Therapeutic Chemical (ATC) class N, ≥1 comorbidity, an estimated glomerular filtration rate (eGFR) <30 mL/min and age ≥60 years. The methodological approach and the individual risk factors presented in this review may provide a new starting point for improved risk assessment.
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spelling pubmed-94571512022-09-09 Systematic Review of Risk Factors Assessed in Predictive Scoring Tools for Drug-Related Problems in Inpatients Jung-Poppe, Lea Nicolaus, Hagen Fabian Roggenhofer, Anna Altenbuchner, Anna Dormann, Harald Pfistermeister, Barbara Maas, Renke J Clin Med Systematic Review Drug-related problems (DRP, defined as adverse drug events/reactions and medication errors) are a common threat for patient safety. With the aim to aid improved allocation of specialist resources and to improve detection and prevention of DRP, numerous predictive scoring tools have been proposed. The external validation and evidence for the transferability of these tools still faces limitations. However, the proposed scoring tools include partly overlapping sets of similar factors, which may allow a new approach to estimate the external usability and validity of individual risk factors. Therefore, we conducted this systematic review and analysis. We identified 14 key studies that assessed 844 candidate risk factors for inclusion into predictive scoring tools. After consolidation to account for overlapping terminology and variable definitions, we assessed each risk factor in the number of studies it was assessed, and, if it was found to be a significant predictor of DRP, whether it was included in a final scoring tool. The latter included intake of ≥ 8 drugs, drugs of the Anatomical Therapeutic Chemical (ATC) class N, ≥1 comorbidity, an estimated glomerular filtration rate (eGFR) <30 mL/min and age ≥60 years. The methodological approach and the individual risk factors presented in this review may provide a new starting point for improved risk assessment. MDPI 2022-09-01 /pmc/articles/PMC9457151/ /pubmed/36079114 http://dx.doi.org/10.3390/jcm11175185 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Jung-Poppe, Lea
Nicolaus, Hagen Fabian
Roggenhofer, Anna
Altenbuchner, Anna
Dormann, Harald
Pfistermeister, Barbara
Maas, Renke
Systematic Review of Risk Factors Assessed in Predictive Scoring Tools for Drug-Related Problems in Inpatients
title Systematic Review of Risk Factors Assessed in Predictive Scoring Tools for Drug-Related Problems in Inpatients
title_full Systematic Review of Risk Factors Assessed in Predictive Scoring Tools for Drug-Related Problems in Inpatients
title_fullStr Systematic Review of Risk Factors Assessed in Predictive Scoring Tools for Drug-Related Problems in Inpatients
title_full_unstemmed Systematic Review of Risk Factors Assessed in Predictive Scoring Tools for Drug-Related Problems in Inpatients
title_short Systematic Review of Risk Factors Assessed in Predictive Scoring Tools for Drug-Related Problems in Inpatients
title_sort systematic review of risk factors assessed in predictive scoring tools for drug-related problems in inpatients
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9457151/
https://www.ncbi.nlm.nih.gov/pubmed/36079114
http://dx.doi.org/10.3390/jcm11175185
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