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Association between Routine Laboratory Parameters and the Severity and Progression of Systemic Sclerosis

(1) Background: Systemic sclerosis (SSc) is a heterogeneous connective tissue disease with a high mortality and morbidity rate. Identification of biomarkers that can predict the evolution of SSc is a key factor in the management of patients. The aim of this study was to assess the association of rou...

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Autores principales: Chikhoune, Liticia, Brousseau, Thierry, Morell-Dubois, Sandrine, Farhat, Meryem Maud, Maillard, Helene, Ledoult, Emmanuel, Lambert, Marc, Yelnik, Cecile, Sanges, Sebastien, Sobanski, Vincent, Hachulla, Eric, Launay, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9457158/
https://www.ncbi.nlm.nih.gov/pubmed/36079017
http://dx.doi.org/10.3390/jcm11175087
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author Chikhoune, Liticia
Brousseau, Thierry
Morell-Dubois, Sandrine
Farhat, Meryem Maud
Maillard, Helene
Ledoult, Emmanuel
Lambert, Marc
Yelnik, Cecile
Sanges, Sebastien
Sobanski, Vincent
Hachulla, Eric
Launay, David
author_facet Chikhoune, Liticia
Brousseau, Thierry
Morell-Dubois, Sandrine
Farhat, Meryem Maud
Maillard, Helene
Ledoult, Emmanuel
Lambert, Marc
Yelnik, Cecile
Sanges, Sebastien
Sobanski, Vincent
Hachulla, Eric
Launay, David
author_sort Chikhoune, Liticia
collection PubMed
description (1) Background: Systemic sclerosis (SSc) is a heterogeneous connective tissue disease with a high mortality and morbidity rate. Identification of biomarkers that can predict the evolution of SSc is a key factor in the management of patients. The aim of this study was to assess the association of routine laboratory parameters, widely used in practice and easily available, with the severity and progression of SSc. (2) Methods: In this retrospective monocentric cohort study, 372 SSc patients were included. We gathered clinical and laboratory data including routine laboratory parameters: C-reactive-protein (CRP), erythrocyte sedimentation rate (ESR), complete blood count, serum sodium and potassium levels, creatinin, urea, ferritin, albumin, uric acid, N-terminal pro-brain natriuretic peptide (NTproBNP), serum protein electrophoresis, and liver enzymes. Associations between these routine laboratory parameters and clinical presentation and outcome were assessed. (3) Results: Median (interquartile range) age was 59.0 (50.0; 68.0) years. White blood cell, monocyte, and neutrophil absolute counts were significantly higher in patients with diffuse cutaneous SSc and with interstitial lung disease (ILD) (p < 0.001). CRP was significantly higher in patients with ILD (p < 0.001). Hemoglobin and ferritin were significantly lower in patients with pulmonary hypertension (PH) including pulmonary arterial hypertension and ILD associated PH (p = 0.016 and 0.046, respectively). Uric acid and NT pro BNP were significantly higher in patients with PH (<0.001). Monocyte count was associated with ILD progression over time. (4) Conclusions: Overall, our study highlights the association of routine laboratory parameters used in current practice with the severity and progression of SSc.
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spelling pubmed-94571582022-09-09 Association between Routine Laboratory Parameters and the Severity and Progression of Systemic Sclerosis Chikhoune, Liticia Brousseau, Thierry Morell-Dubois, Sandrine Farhat, Meryem Maud Maillard, Helene Ledoult, Emmanuel Lambert, Marc Yelnik, Cecile Sanges, Sebastien Sobanski, Vincent Hachulla, Eric Launay, David J Clin Med Article (1) Background: Systemic sclerosis (SSc) is a heterogeneous connective tissue disease with a high mortality and morbidity rate. Identification of biomarkers that can predict the evolution of SSc is a key factor in the management of patients. The aim of this study was to assess the association of routine laboratory parameters, widely used in practice and easily available, with the severity and progression of SSc. (2) Methods: In this retrospective monocentric cohort study, 372 SSc patients were included. We gathered clinical and laboratory data including routine laboratory parameters: C-reactive-protein (CRP), erythrocyte sedimentation rate (ESR), complete blood count, serum sodium and potassium levels, creatinin, urea, ferritin, albumin, uric acid, N-terminal pro-brain natriuretic peptide (NTproBNP), serum protein electrophoresis, and liver enzymes. Associations between these routine laboratory parameters and clinical presentation and outcome were assessed. (3) Results: Median (interquartile range) age was 59.0 (50.0; 68.0) years. White blood cell, monocyte, and neutrophil absolute counts were significantly higher in patients with diffuse cutaneous SSc and with interstitial lung disease (ILD) (p < 0.001). CRP was significantly higher in patients with ILD (p < 0.001). Hemoglobin and ferritin were significantly lower in patients with pulmonary hypertension (PH) including pulmonary arterial hypertension and ILD associated PH (p = 0.016 and 0.046, respectively). Uric acid and NT pro BNP were significantly higher in patients with PH (<0.001). Monocyte count was associated with ILD progression over time. (4) Conclusions: Overall, our study highlights the association of routine laboratory parameters used in current practice with the severity and progression of SSc. MDPI 2022-08-30 /pmc/articles/PMC9457158/ /pubmed/36079017 http://dx.doi.org/10.3390/jcm11175087 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chikhoune, Liticia
Brousseau, Thierry
Morell-Dubois, Sandrine
Farhat, Meryem Maud
Maillard, Helene
Ledoult, Emmanuel
Lambert, Marc
Yelnik, Cecile
Sanges, Sebastien
Sobanski, Vincent
Hachulla, Eric
Launay, David
Association between Routine Laboratory Parameters and the Severity and Progression of Systemic Sclerosis
title Association between Routine Laboratory Parameters and the Severity and Progression of Systemic Sclerosis
title_full Association between Routine Laboratory Parameters and the Severity and Progression of Systemic Sclerosis
title_fullStr Association between Routine Laboratory Parameters and the Severity and Progression of Systemic Sclerosis
title_full_unstemmed Association between Routine Laboratory Parameters and the Severity and Progression of Systemic Sclerosis
title_short Association between Routine Laboratory Parameters and the Severity and Progression of Systemic Sclerosis
title_sort association between routine laboratory parameters and the severity and progression of systemic sclerosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9457158/
https://www.ncbi.nlm.nih.gov/pubmed/36079017
http://dx.doi.org/10.3390/jcm11175087
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