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Association between Routine Laboratory Parameters and the Severity and Progression of Systemic Sclerosis
(1) Background: Systemic sclerosis (SSc) is a heterogeneous connective tissue disease with a high mortality and morbidity rate. Identification of biomarkers that can predict the evolution of SSc is a key factor in the management of patients. The aim of this study was to assess the association of rou...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9457158/ https://www.ncbi.nlm.nih.gov/pubmed/36079017 http://dx.doi.org/10.3390/jcm11175087 |
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author | Chikhoune, Liticia Brousseau, Thierry Morell-Dubois, Sandrine Farhat, Meryem Maud Maillard, Helene Ledoult, Emmanuel Lambert, Marc Yelnik, Cecile Sanges, Sebastien Sobanski, Vincent Hachulla, Eric Launay, David |
author_facet | Chikhoune, Liticia Brousseau, Thierry Morell-Dubois, Sandrine Farhat, Meryem Maud Maillard, Helene Ledoult, Emmanuel Lambert, Marc Yelnik, Cecile Sanges, Sebastien Sobanski, Vincent Hachulla, Eric Launay, David |
author_sort | Chikhoune, Liticia |
collection | PubMed |
description | (1) Background: Systemic sclerosis (SSc) is a heterogeneous connective tissue disease with a high mortality and morbidity rate. Identification of biomarkers that can predict the evolution of SSc is a key factor in the management of patients. The aim of this study was to assess the association of routine laboratory parameters, widely used in practice and easily available, with the severity and progression of SSc. (2) Methods: In this retrospective monocentric cohort study, 372 SSc patients were included. We gathered clinical and laboratory data including routine laboratory parameters: C-reactive-protein (CRP), erythrocyte sedimentation rate (ESR), complete blood count, serum sodium and potassium levels, creatinin, urea, ferritin, albumin, uric acid, N-terminal pro-brain natriuretic peptide (NTproBNP), serum protein electrophoresis, and liver enzymes. Associations between these routine laboratory parameters and clinical presentation and outcome were assessed. (3) Results: Median (interquartile range) age was 59.0 (50.0; 68.0) years. White blood cell, monocyte, and neutrophil absolute counts were significantly higher in patients with diffuse cutaneous SSc and with interstitial lung disease (ILD) (p < 0.001). CRP was significantly higher in patients with ILD (p < 0.001). Hemoglobin and ferritin were significantly lower in patients with pulmonary hypertension (PH) including pulmonary arterial hypertension and ILD associated PH (p = 0.016 and 0.046, respectively). Uric acid and NT pro BNP were significantly higher in patients with PH (<0.001). Monocyte count was associated with ILD progression over time. (4) Conclusions: Overall, our study highlights the association of routine laboratory parameters used in current practice with the severity and progression of SSc. |
format | Online Article Text |
id | pubmed-9457158 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94571582022-09-09 Association between Routine Laboratory Parameters and the Severity and Progression of Systemic Sclerosis Chikhoune, Liticia Brousseau, Thierry Morell-Dubois, Sandrine Farhat, Meryem Maud Maillard, Helene Ledoult, Emmanuel Lambert, Marc Yelnik, Cecile Sanges, Sebastien Sobanski, Vincent Hachulla, Eric Launay, David J Clin Med Article (1) Background: Systemic sclerosis (SSc) is a heterogeneous connective tissue disease with a high mortality and morbidity rate. Identification of biomarkers that can predict the evolution of SSc is a key factor in the management of patients. The aim of this study was to assess the association of routine laboratory parameters, widely used in practice and easily available, with the severity and progression of SSc. (2) Methods: In this retrospective monocentric cohort study, 372 SSc patients were included. We gathered clinical and laboratory data including routine laboratory parameters: C-reactive-protein (CRP), erythrocyte sedimentation rate (ESR), complete blood count, serum sodium and potassium levels, creatinin, urea, ferritin, albumin, uric acid, N-terminal pro-brain natriuretic peptide (NTproBNP), serum protein electrophoresis, and liver enzymes. Associations between these routine laboratory parameters and clinical presentation and outcome were assessed. (3) Results: Median (interquartile range) age was 59.0 (50.0; 68.0) years. White blood cell, monocyte, and neutrophil absolute counts were significantly higher in patients with diffuse cutaneous SSc and with interstitial lung disease (ILD) (p < 0.001). CRP was significantly higher in patients with ILD (p < 0.001). Hemoglobin and ferritin were significantly lower in patients with pulmonary hypertension (PH) including pulmonary arterial hypertension and ILD associated PH (p = 0.016 and 0.046, respectively). Uric acid and NT pro BNP were significantly higher in patients with PH (<0.001). Monocyte count was associated with ILD progression over time. (4) Conclusions: Overall, our study highlights the association of routine laboratory parameters used in current practice with the severity and progression of SSc. MDPI 2022-08-30 /pmc/articles/PMC9457158/ /pubmed/36079017 http://dx.doi.org/10.3390/jcm11175087 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Chikhoune, Liticia Brousseau, Thierry Morell-Dubois, Sandrine Farhat, Meryem Maud Maillard, Helene Ledoult, Emmanuel Lambert, Marc Yelnik, Cecile Sanges, Sebastien Sobanski, Vincent Hachulla, Eric Launay, David Association between Routine Laboratory Parameters and the Severity and Progression of Systemic Sclerosis |
title | Association between Routine Laboratory Parameters and the Severity and Progression of Systemic Sclerosis |
title_full | Association between Routine Laboratory Parameters and the Severity and Progression of Systemic Sclerosis |
title_fullStr | Association between Routine Laboratory Parameters and the Severity and Progression of Systemic Sclerosis |
title_full_unstemmed | Association between Routine Laboratory Parameters and the Severity and Progression of Systemic Sclerosis |
title_short | Association between Routine Laboratory Parameters and the Severity and Progression of Systemic Sclerosis |
title_sort | association between routine laboratory parameters and the severity and progression of systemic sclerosis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9457158/ https://www.ncbi.nlm.nih.gov/pubmed/36079017 http://dx.doi.org/10.3390/jcm11175087 |
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