Manipulating complex chromatin folding via CRISPR-guided bioorthogonal chemistry

Precise manipulation of chromatin folding is important for understanding the relationship between the three-dimensional genome and nuclear function. Existing tools can reversibly establish individual chromatin loops but fail to manipulate two or more chromatin loops. Here, we engineer a powerful CRI...

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Detalles Bibliográficos
Autores principales: Qin, Geng, Yang, Jie, Zhao, Chuanqi, Ren, Jinsong, Qu, Xiaogang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Physical Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9457169/
https://www.ncbi.nlm.nih.gov/pubmed/36037371
http://dx.doi.org/10.1073/pnas.2204725119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9457169/
https://www.ncbi.nlm.nih.gov/pubmed/36037371
http://dx.doi.org/10.1073/pnas.2204725119

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