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Manipulating complex chromatin folding via CRISPR-guided bioorthogonal chemistry
Precise manipulation of chromatin folding is important for understanding the relationship between the three-dimensional genome and nuclear function. Existing tools can reversibly establish individual chromatin loops but fail to manipulate two or more chromatin loops. Here, we engineer a powerful CRI...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9457169/ https://www.ncbi.nlm.nih.gov/pubmed/36037371 http://dx.doi.org/10.1073/pnas.2204725119 |