Alum-anchored intratumoral retention improves the tolerability and antitumor efficacy of type I interferon therapies

Effective antitumor immunity in mice requires activation of the type I interferon (IFN) response pathway. IFNα and IFNβ therapies have proven promising in humans, but suffer from limited efficacy and high toxicity. Intratumoral IFN retention ameliorates systemic toxicity, but given the complexity of...

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Detalles Bibliográficos
Autores principales: Lutz, Emi A., Agarwal, Yash, Momin, Noor, Cowles, Sarah C., Palmeri, Joseph R., Duong, Ellen, Hornet, Vladlena, Sheen, Allison, Lax, Brianna M., Rothschilds, Adrienne M., Irvine, Darrell J., Spranger, Stefani, Wittrup, K. Dane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9457244/
https://www.ncbi.nlm.nih.gov/pubmed/36037341
http://dx.doi.org/10.1073/pnas.2205983119

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