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Effects of on-Table Extubation after Pediatric Cardiac Surgery
Background: Enhanced recovery after surgery (ERAS) protocols are utilizing a multidisciplinary approach, reassessing physiology to improve clinical outcomes, reducing length of hospital stay (LOS) stay, resulting in cost reduction. Since its introduction in colorectal surgery. the concept has been u...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9457288/ https://www.ncbi.nlm.nih.gov/pubmed/36079121 http://dx.doi.org/10.3390/jcm11175186 |
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author | Baehner, Torsten Pruemm, Philipp Vergnat, Mathieu Asfour, Boulos Straßberger-Nerschbach, Nadine Kirfel, Andrea Hamann, Michael Mayr, Andreas Schindler, Ehrenfried Velten, Markus Wittmann, Maria |
author_facet | Baehner, Torsten Pruemm, Philipp Vergnat, Mathieu Asfour, Boulos Straßberger-Nerschbach, Nadine Kirfel, Andrea Hamann, Michael Mayr, Andreas Schindler, Ehrenfried Velten, Markus Wittmann, Maria |
author_sort | Baehner, Torsten |
collection | PubMed |
description | Background: Enhanced recovery after surgery (ERAS) protocols are utilizing a multidisciplinary approach, reassessing physiology to improve clinical outcomes, reducing length of hospital stay (LOS) stay, resulting in cost reduction. Since its introduction in colorectal surgery. the concept has been utilized in various fields and benefits have been recognized also in adult cardiac surgery. However, ERAS concepts in pediatric cardiac surgery are not yet widely established. Therefore, the aim of the present study was to assess the effects of on-table extubation (OTE) after pediatric cardiac surgery compared to the standard approach of delayed extubation (DET) during intensive care treatment. Study Design and Methods: We performed a retrospective analysis of all pediatric cardiac surgery cases performed in children below the age of two years using cardiopulmonary bypass at our institution in 2021. Exclusion criteria were emergency and off pump surgeries as well as children already ventilated preoperatively. Results: OTE children were older (267.3 days vs. 126.7 days, p < 0.001), had a higher body weight (7.0 ± 1.6 kg vs. 4.9 ± 1.9 kg, p < 0.001), showed significantly reduced duration of ICU treatment (75.9 ± 56.8 h vs. 217.2 ± 211.4 h, p < 0.001) and LOS (11.1 ± 10.2 days vs. 20.1 ± 23.4 days; p = 0.001) compared to DET group. Furthermore, OTE children had significantly fewer catecholamine dependencies at 12-, 24-, 48-, and 72-h post-surgery, while DET children showed a significantly increased intrafluid shift relative to body weight (109.1 ± 82.0 mL/kg body weight vs. 63.0 ± 63.0 mL/kg body weight, p < 0.001). After propensity score matching considering age, weight, bypass duration, Society of Thoracic Surgeons-European Association for Cardio-Thoracic Surgery Mortality (STATS)-Score, and the outcome variables, including duration of ICU treatment, catecholamine dependencies, and hospital LOS, findings significantly favored the OTE group. Conclusion: Our results suggest that on-table extubation after pediatric cardiac surgery is feasible and in our cohort was associated with a favorable postoperative course. |
format | Online Article Text |
id | pubmed-9457288 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94572882022-09-09 Effects of on-Table Extubation after Pediatric Cardiac Surgery Baehner, Torsten Pruemm, Philipp Vergnat, Mathieu Asfour, Boulos Straßberger-Nerschbach, Nadine Kirfel, Andrea Hamann, Michael Mayr, Andreas Schindler, Ehrenfried Velten, Markus Wittmann, Maria J Clin Med Article Background: Enhanced recovery after surgery (ERAS) protocols are utilizing a multidisciplinary approach, reassessing physiology to improve clinical outcomes, reducing length of hospital stay (LOS) stay, resulting in cost reduction. Since its introduction in colorectal surgery. the concept has been utilized in various fields and benefits have been recognized also in adult cardiac surgery. However, ERAS concepts in pediatric cardiac surgery are not yet widely established. Therefore, the aim of the present study was to assess the effects of on-table extubation (OTE) after pediatric cardiac surgery compared to the standard approach of delayed extubation (DET) during intensive care treatment. Study Design and Methods: We performed a retrospective analysis of all pediatric cardiac surgery cases performed in children below the age of two years using cardiopulmonary bypass at our institution in 2021. Exclusion criteria were emergency and off pump surgeries as well as children already ventilated preoperatively. Results: OTE children were older (267.3 days vs. 126.7 days, p < 0.001), had a higher body weight (7.0 ± 1.6 kg vs. 4.9 ± 1.9 kg, p < 0.001), showed significantly reduced duration of ICU treatment (75.9 ± 56.8 h vs. 217.2 ± 211.4 h, p < 0.001) and LOS (11.1 ± 10.2 days vs. 20.1 ± 23.4 days; p = 0.001) compared to DET group. Furthermore, OTE children had significantly fewer catecholamine dependencies at 12-, 24-, 48-, and 72-h post-surgery, while DET children showed a significantly increased intrafluid shift relative to body weight (109.1 ± 82.0 mL/kg body weight vs. 63.0 ± 63.0 mL/kg body weight, p < 0.001). After propensity score matching considering age, weight, bypass duration, Society of Thoracic Surgeons-European Association for Cardio-Thoracic Surgery Mortality (STATS)-Score, and the outcome variables, including duration of ICU treatment, catecholamine dependencies, and hospital LOS, findings significantly favored the OTE group. Conclusion: Our results suggest that on-table extubation after pediatric cardiac surgery is feasible and in our cohort was associated with a favorable postoperative course. MDPI 2022-09-01 /pmc/articles/PMC9457288/ /pubmed/36079121 http://dx.doi.org/10.3390/jcm11175186 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Baehner, Torsten Pruemm, Philipp Vergnat, Mathieu Asfour, Boulos Straßberger-Nerschbach, Nadine Kirfel, Andrea Hamann, Michael Mayr, Andreas Schindler, Ehrenfried Velten, Markus Wittmann, Maria Effects of on-Table Extubation after Pediatric Cardiac Surgery |
title | Effects of on-Table Extubation after Pediatric Cardiac Surgery |
title_full | Effects of on-Table Extubation after Pediatric Cardiac Surgery |
title_fullStr | Effects of on-Table Extubation after Pediatric Cardiac Surgery |
title_full_unstemmed | Effects of on-Table Extubation after Pediatric Cardiac Surgery |
title_short | Effects of on-Table Extubation after Pediatric Cardiac Surgery |
title_sort | effects of on-table extubation after pediatric cardiac surgery |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9457288/ https://www.ncbi.nlm.nih.gov/pubmed/36079121 http://dx.doi.org/10.3390/jcm11175186 |
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