Cross-talk between IL-6 trans-signaling and AIM2 inflammasome/IL-1β axes bridge innate immunity and epithelial apoptosis to promote emphysema

Pulmonary emphysema is associated with dysregulated innate immune responses that promote chronic pulmonary inflammation and alveolar apoptosis, culminating in lung destruction. However, the molecular regulators of innate immunity that promote emphysema are ill-defined. Here, we investigated whether...

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Detalles Bibliográficos
Autores principales: Ruwanpura, Saleela M., McLeod, Louise, Dousha, Lovisa F., Seow, Huei J., West, Alison C., West, Alice J., Weng, Teresa, Alanazi, Mohammad, MacDonald, Martin, King, Paul T., Bardin, Philip G., Gabay, Cem, Klinman, Dennis M., Bozinovski, Steven, Vlahos, Ross, Anderson, Gary P., Rose-John, Stefan, Saad, Mohamed I., Jenkins, Brendan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9457334/
https://www.ncbi.nlm.nih.gov/pubmed/36037355
http://dx.doi.org/10.1073/pnas.2201494119

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