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Nano-Ag Particles Embedded in C-Matrix: Preparation, Properties and Application in Cell Metabolism

The application of nano-Ag grains as antiviral and antibacterial materials is widely known since ancient times. The problem is the toxicity of the bulk or big-size grain materials. It is known that nano-sized silver grains affect human and animal cells in some medical treatments. The aim of this stu...

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Autores principales: Terpilowska, Sylwia, Gluszek, Stanislaw, Czerwosz, Elzbieta, Wronka, Halina, Firek, Piotr, Szmidt, Jan, Suchanska, Malgorzata, Keczkowska, Justyna, Kaczmarska, Bozena, Kozlowski, Mirosław, Diduszko, Ryszard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9457446/
https://www.ncbi.nlm.nih.gov/pubmed/36079207
http://dx.doi.org/10.3390/ma15175826
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author Terpilowska, Sylwia
Gluszek, Stanislaw
Czerwosz, Elzbieta
Wronka, Halina
Firek, Piotr
Szmidt, Jan
Suchanska, Malgorzata
Keczkowska, Justyna
Kaczmarska, Bozena
Kozlowski, Mirosław
Diduszko, Ryszard
author_facet Terpilowska, Sylwia
Gluszek, Stanislaw
Czerwosz, Elzbieta
Wronka, Halina
Firek, Piotr
Szmidt, Jan
Suchanska, Malgorzata
Keczkowska, Justyna
Kaczmarska, Bozena
Kozlowski, Mirosław
Diduszko, Ryszard
author_sort Terpilowska, Sylwia
collection PubMed
description The application of nano-Ag grains as antiviral and antibacterial materials is widely known since ancient times. The problem is the toxicity of the bulk or big-size grain materials. It is known that nano-sized silver grains affect human and animal cells in some medical treatments. The aim of this study is to investigate the influence of nano-Ag grains embedded in a carbonaceous matrix on cytotoxicity, genotoxicity in fibroblasts, and mutagenicity. The nanocomposite film is composed of silver nanograins embedded in a carbonaceous matrix and it was obtained via the PVD method by deposition from two separated sources of fullerenes and silver acetate powders. This method allows for the preparation of material in the form of a film or powder, in which Ag nanograins are stabilized by a carbon network. The structure and morphology of this material were studied using SEM/EDX, XRD, and Raman spectroscopy. The toxicology studies were performed for various types of the material differing in the size of Ag nanograins. Furthermore, it was found that these properties, such as cell viability, genotoxicity, and mutagenicity, depend on Ag grain size.
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spelling pubmed-94574462022-09-09 Nano-Ag Particles Embedded in C-Matrix: Preparation, Properties and Application in Cell Metabolism Terpilowska, Sylwia Gluszek, Stanislaw Czerwosz, Elzbieta Wronka, Halina Firek, Piotr Szmidt, Jan Suchanska, Malgorzata Keczkowska, Justyna Kaczmarska, Bozena Kozlowski, Mirosław Diduszko, Ryszard Materials (Basel) Article The application of nano-Ag grains as antiviral and antibacterial materials is widely known since ancient times. The problem is the toxicity of the bulk or big-size grain materials. It is known that nano-sized silver grains affect human and animal cells in some medical treatments. The aim of this study is to investigate the influence of nano-Ag grains embedded in a carbonaceous matrix on cytotoxicity, genotoxicity in fibroblasts, and mutagenicity. The nanocomposite film is composed of silver nanograins embedded in a carbonaceous matrix and it was obtained via the PVD method by deposition from two separated sources of fullerenes and silver acetate powders. This method allows for the preparation of material in the form of a film or powder, in which Ag nanograins are stabilized by a carbon network. The structure and morphology of this material were studied using SEM/EDX, XRD, and Raman spectroscopy. The toxicology studies were performed for various types of the material differing in the size of Ag nanograins. Furthermore, it was found that these properties, such as cell viability, genotoxicity, and mutagenicity, depend on Ag grain size. MDPI 2022-08-24 /pmc/articles/PMC9457446/ /pubmed/36079207 http://dx.doi.org/10.3390/ma15175826 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Terpilowska, Sylwia
Gluszek, Stanislaw
Czerwosz, Elzbieta
Wronka, Halina
Firek, Piotr
Szmidt, Jan
Suchanska, Malgorzata
Keczkowska, Justyna
Kaczmarska, Bozena
Kozlowski, Mirosław
Diduszko, Ryszard
Nano-Ag Particles Embedded in C-Matrix: Preparation, Properties and Application in Cell Metabolism
title Nano-Ag Particles Embedded in C-Matrix: Preparation, Properties and Application in Cell Metabolism
title_full Nano-Ag Particles Embedded in C-Matrix: Preparation, Properties and Application in Cell Metabolism
title_fullStr Nano-Ag Particles Embedded in C-Matrix: Preparation, Properties and Application in Cell Metabolism
title_full_unstemmed Nano-Ag Particles Embedded in C-Matrix: Preparation, Properties and Application in Cell Metabolism
title_short Nano-Ag Particles Embedded in C-Matrix: Preparation, Properties and Application in Cell Metabolism
title_sort nano-ag particles embedded in c-matrix: preparation, properties and application in cell metabolism
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9457446/
https://www.ncbi.nlm.nih.gov/pubmed/36079207
http://dx.doi.org/10.3390/ma15175826
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