LAPTM5 mediates immature B cell apoptosis and B cell tolerance by regulating the WWP2-PTEN-AKT pathway

Elimination of autoreactive developing B cells is an important mechanism to prevent autoantibody production. However, how B cell receptor (BCR) signaling triggers apoptosis of immature B cells remains poorly understood. We show that BCR stimulation up-regulates the expression of the lysosomal-associ...

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Detalles Bibliográficos
Autores principales: Wang, Ying, Liu, Jun, Akatsu, Chizuru, Zhang, Runyun, Zhang, Hai, Zhu, Han, Liu, Kangwei, Zhu, Han-Ying, Min, Qing, Meng, Xin, Cui, Chaoqun, Tang, Yue, Yu, Meiping, Li, Yaxuan, Feng, Xiaoqian, Wei, Hao, Wen, Zichao, Ji, Sihan, Weigert, Martin G., Tsubata, Takeshi, Wang, Ji-Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9457450/
https://www.ncbi.nlm.nih.gov/pubmed/36037365
http://dx.doi.org/10.1073/pnas.2205629119

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