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Deciphering Conformational Changes of the GDP-Bound NRAS Induced by Mutations G13D, Q61R, and C118S through Gaussian Accelerated Molecular Dynamic Simulations

The conformational changes in switch domains significantly affect the activity of NRAS. Gaussian-accelerated molecular dynamics (GaMD) simulations of three separate replicas were performed to decipher the effects of G13D, Q16R, and C118S on the conformational transformation of the GDP-bound NRAS. Th...

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Detalles Bibliográficos
Autores principales:	Yu, Zhiping, Su, Hongyi, Chen, Jianzhong, Hu, Guodong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9457619/ https://www.ncbi.nlm.nih.gov/pubmed/36080363 http://dx.doi.org/10.3390/molecules27175596

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