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Radionuclides for Targeted Therapy: Physical Properties

A search in PubMed revealed that 72 radionuclides have been considered for molecular or functional targeted radionuclide therapy. As radionuclide therapies increase in number and variations, it is important to understand the role of the radionuclide and the various characteristics that can render it...

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Autores principales: Stokke, Caroline, Kvassheim, Monika, Blakkisrud, Johan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9457625/
https://www.ncbi.nlm.nih.gov/pubmed/36080198
http://dx.doi.org/10.3390/molecules27175429
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author Stokke, Caroline
Kvassheim, Monika
Blakkisrud, Johan
author_facet Stokke, Caroline
Kvassheim, Monika
Blakkisrud, Johan
author_sort Stokke, Caroline
collection PubMed
description A search in PubMed revealed that 72 radionuclides have been considered for molecular or functional targeted radionuclide therapy. As radionuclide therapies increase in number and variations, it is important to understand the role of the radionuclide and the various characteristics that can render it either useful or useless. This review focuses on the physical characteristics of radionuclides that are relevant for radionuclide therapy, such as linear energy transfer, relative biological effectiveness, range, half-life, imaging properties, and radiation protection considerations. All these properties vary considerably between radionuclides and can be optimised for specific targets. Properties that are advantageous for some applications can sometimes be drawbacks for others; for instance, radionuclides that enable easy imaging can introduce more radiation protection concerns than others. Similarly, a long radiation range is beneficial in targets with heterogeneous uptake, but it also increases the radiation dose to tissues surrounding the target, and, hence, a shorter range is likely more beneficial with homogeneous uptake. While one cannot select a collection of characteristics as each radionuclide comes with an unchangeable set, all the 72 radionuclides investigated for therapy—and many more that have not yet been investigated—provide numerous sets to choose between.
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spelling pubmed-94576252022-09-09 Radionuclides for Targeted Therapy: Physical Properties Stokke, Caroline Kvassheim, Monika Blakkisrud, Johan Molecules Review A search in PubMed revealed that 72 radionuclides have been considered for molecular or functional targeted radionuclide therapy. As radionuclide therapies increase in number and variations, it is important to understand the role of the radionuclide and the various characteristics that can render it either useful or useless. This review focuses on the physical characteristics of radionuclides that are relevant for radionuclide therapy, such as linear energy transfer, relative biological effectiveness, range, half-life, imaging properties, and radiation protection considerations. All these properties vary considerably between radionuclides and can be optimised for specific targets. Properties that are advantageous for some applications can sometimes be drawbacks for others; for instance, radionuclides that enable easy imaging can introduce more radiation protection concerns than others. Similarly, a long radiation range is beneficial in targets with heterogeneous uptake, but it also increases the radiation dose to tissues surrounding the target, and, hence, a shorter range is likely more beneficial with homogeneous uptake. While one cannot select a collection of characteristics as each radionuclide comes with an unchangeable set, all the 72 radionuclides investigated for therapy—and many more that have not yet been investigated—provide numerous sets to choose between. MDPI 2022-08-25 /pmc/articles/PMC9457625/ /pubmed/36080198 http://dx.doi.org/10.3390/molecules27175429 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Stokke, Caroline
Kvassheim, Monika
Blakkisrud, Johan
Radionuclides for Targeted Therapy: Physical Properties
title Radionuclides for Targeted Therapy: Physical Properties
title_full Radionuclides for Targeted Therapy: Physical Properties
title_fullStr Radionuclides for Targeted Therapy: Physical Properties
title_full_unstemmed Radionuclides for Targeted Therapy: Physical Properties
title_short Radionuclides for Targeted Therapy: Physical Properties
title_sort radionuclides for targeted therapy: physical properties
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9457625/
https://www.ncbi.nlm.nih.gov/pubmed/36080198
http://dx.doi.org/10.3390/molecules27175429
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