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Evidence accumulation, not ‘self-control’, explains dorsolateral prefrontal activation during normative choice

What role do regions like the dorsolateral prefrontal cortex (dlPFC) play in normative behavior (e.g., generosity, healthy eating)? Some models suggest that dlPFC activation during normative choice reflects controlled inhibition or modulation of default hedonistic preferences. Here, we develop an al...

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Detalles Bibliográficos
Autores principales: Hutcherson, Cendri A, Tusche, Anita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9457682/
https://www.ncbi.nlm.nih.gov/pubmed/36074557
http://dx.doi.org/10.7554/eLife.65661
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author Hutcherson, Cendri A
Tusche, Anita
author_facet Hutcherson, Cendri A
Tusche, Anita
author_sort Hutcherson, Cendri A
collection PubMed
description What role do regions like the dorsolateral prefrontal cortex (dlPFC) play in normative behavior (e.g., generosity, healthy eating)? Some models suggest that dlPFC activation during normative choice reflects controlled inhibition or modulation of default hedonistic preferences. Here, we develop an alternative account, showing that evidence accumulation models predict trial-by-trial variation in dlPFC response across three fMRI paradigms and two self-control contexts (altruistic sacrifice and healthy eating). Using these models to simulate a variety of self-control dilemmas generated a novel prediction: although dlPFC activity might typically increase for norm-consistent choices, deliberate self-regulation focused on normative goals should decrease or even reverse this pattern (i.e., greater dlPFC response for hedonistic, self-interested choices). We confirmed these predictions in both altruistic and dietary choice contexts. Our results suggest that dlPFC response during normative choice may depend more on value-based evidence accumulation than inhibition of our baser instincts.
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spelling pubmed-94576822022-09-09 Evidence accumulation, not ‘self-control’, explains dorsolateral prefrontal activation during normative choice Hutcherson, Cendri A Tusche, Anita eLife Neuroscience What role do regions like the dorsolateral prefrontal cortex (dlPFC) play in normative behavior (e.g., generosity, healthy eating)? Some models suggest that dlPFC activation during normative choice reflects controlled inhibition or modulation of default hedonistic preferences. Here, we develop an alternative account, showing that evidence accumulation models predict trial-by-trial variation in dlPFC response across three fMRI paradigms and two self-control contexts (altruistic sacrifice and healthy eating). Using these models to simulate a variety of self-control dilemmas generated a novel prediction: although dlPFC activity might typically increase for norm-consistent choices, deliberate self-regulation focused on normative goals should decrease or even reverse this pattern (i.e., greater dlPFC response for hedonistic, self-interested choices). We confirmed these predictions in both altruistic and dietary choice contexts. Our results suggest that dlPFC response during normative choice may depend more on value-based evidence accumulation than inhibition of our baser instincts. eLife Sciences Publications, Ltd 2022-09-08 /pmc/articles/PMC9457682/ /pubmed/36074557 http://dx.doi.org/10.7554/eLife.65661 Text en © 2022, Hutcherson and Tusche https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Hutcherson, Cendri A
Tusche, Anita
Evidence accumulation, not ‘self-control’, explains dorsolateral prefrontal activation during normative choice
title Evidence accumulation, not ‘self-control’, explains dorsolateral prefrontal activation during normative choice
title_full Evidence accumulation, not ‘self-control’, explains dorsolateral prefrontal activation during normative choice
title_fullStr Evidence accumulation, not ‘self-control’, explains dorsolateral prefrontal activation during normative choice
title_full_unstemmed Evidence accumulation, not ‘self-control’, explains dorsolateral prefrontal activation during normative choice
title_short Evidence accumulation, not ‘self-control’, explains dorsolateral prefrontal activation during normative choice
title_sort evidence accumulation, not ‘self-control’, explains dorsolateral prefrontal activation during normative choice
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9457682/
https://www.ncbi.nlm.nih.gov/pubmed/36074557
http://dx.doi.org/10.7554/eLife.65661
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