Cargando…
Evidence accumulation, not ‘self-control’, explains dorsolateral prefrontal activation during normative choice
What role do regions like the dorsolateral prefrontal cortex (dlPFC) play in normative behavior (e.g., generosity, healthy eating)? Some models suggest that dlPFC activation during normative choice reflects controlled inhibition or modulation of default hedonistic preferences. Here, we develop an al...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9457682/ https://www.ncbi.nlm.nih.gov/pubmed/36074557 http://dx.doi.org/10.7554/eLife.65661 |
_version_ | 1784786115761274880 |
---|---|
author | Hutcherson, Cendri A Tusche, Anita |
author_facet | Hutcherson, Cendri A Tusche, Anita |
author_sort | Hutcherson, Cendri A |
collection | PubMed |
description | What role do regions like the dorsolateral prefrontal cortex (dlPFC) play in normative behavior (e.g., generosity, healthy eating)? Some models suggest that dlPFC activation during normative choice reflects controlled inhibition or modulation of default hedonistic preferences. Here, we develop an alternative account, showing that evidence accumulation models predict trial-by-trial variation in dlPFC response across three fMRI paradigms and two self-control contexts (altruistic sacrifice and healthy eating). Using these models to simulate a variety of self-control dilemmas generated a novel prediction: although dlPFC activity might typically increase for norm-consistent choices, deliberate self-regulation focused on normative goals should decrease or even reverse this pattern (i.e., greater dlPFC response for hedonistic, self-interested choices). We confirmed these predictions in both altruistic and dietary choice contexts. Our results suggest that dlPFC response during normative choice may depend more on value-based evidence accumulation than inhibition of our baser instincts. |
format | Online Article Text |
id | pubmed-9457682 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-94576822022-09-09 Evidence accumulation, not ‘self-control’, explains dorsolateral prefrontal activation during normative choice Hutcherson, Cendri A Tusche, Anita eLife Neuroscience What role do regions like the dorsolateral prefrontal cortex (dlPFC) play in normative behavior (e.g., generosity, healthy eating)? Some models suggest that dlPFC activation during normative choice reflects controlled inhibition or modulation of default hedonistic preferences. Here, we develop an alternative account, showing that evidence accumulation models predict trial-by-trial variation in dlPFC response across three fMRI paradigms and two self-control contexts (altruistic sacrifice and healthy eating). Using these models to simulate a variety of self-control dilemmas generated a novel prediction: although dlPFC activity might typically increase for norm-consistent choices, deliberate self-regulation focused on normative goals should decrease or even reverse this pattern (i.e., greater dlPFC response for hedonistic, self-interested choices). We confirmed these predictions in both altruistic and dietary choice contexts. Our results suggest that dlPFC response during normative choice may depend more on value-based evidence accumulation than inhibition of our baser instincts. eLife Sciences Publications, Ltd 2022-09-08 /pmc/articles/PMC9457682/ /pubmed/36074557 http://dx.doi.org/10.7554/eLife.65661 Text en © 2022, Hutcherson and Tusche https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Hutcherson, Cendri A Tusche, Anita Evidence accumulation, not ‘self-control’, explains dorsolateral prefrontal activation during normative choice |
title | Evidence accumulation, not ‘self-control’, explains dorsolateral prefrontal activation during normative choice |
title_full | Evidence accumulation, not ‘self-control’, explains dorsolateral prefrontal activation during normative choice |
title_fullStr | Evidence accumulation, not ‘self-control’, explains dorsolateral prefrontal activation during normative choice |
title_full_unstemmed | Evidence accumulation, not ‘self-control’, explains dorsolateral prefrontal activation during normative choice |
title_short | Evidence accumulation, not ‘self-control’, explains dorsolateral prefrontal activation during normative choice |
title_sort | evidence accumulation, not ‘self-control’, explains dorsolateral prefrontal activation during normative choice |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9457682/ https://www.ncbi.nlm.nih.gov/pubmed/36074557 http://dx.doi.org/10.7554/eLife.65661 |
work_keys_str_mv | AT hutchersoncendria evidenceaccumulationnotselfcontrolexplainsdorsolateralprefrontalactivationduringnormativechoice AT tuscheanita evidenceaccumulationnotselfcontrolexplainsdorsolateralprefrontalactivationduringnormativechoice |