Single-molecule analysis of the entire perfringolysin O pore formation pathway

The cholesterol-dependent cytolysin perfringolysin O (PFO) is secreted by Clostridium perfringens as a bacterial virulence factor able to form giant ring-shaped pores that perforate and ultimately lyse mammalian cell membranes. To resolve the kinetics of all steps in the assembly pathway, we have us...

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Detalles Bibliográficos
Autores principales: McGuinness, Conall, Walsh, James C, Bayly-Jones, Charles, Dunstone, Michelle A, Christie, Michelle P, Morton, Craig J, Parker, Michael W, Böcking, Till
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9457685/
https://www.ncbi.nlm.nih.gov/pubmed/36000711
http://dx.doi.org/10.7554/eLife.74901

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9457685/
https://www.ncbi.nlm.nih.gov/pubmed/36000711
http://dx.doi.org/10.7554/eLife.74901

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