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Environmentally Safe Photodynamic Control of Aedes aegypti Using Sunlight-Activated Synthetic Curcumin: Photodegradation, Aquatic Ecotoxicity, and Field Trial

This study reports curcumin as an efficient photolarvicide against Aedes aegypti larvae under natural light illumination. Larval mortality and pupal formation were monitored daily for 21 days under simulated field conditions. In a sucrose-containing formulation, a lethal time 50 ([Formula: see text]...

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Detalles Bibliográficos
Autores principales: Lima, Alessandra R., Silva, Cicera M., da Silva, Lucas M., Machulek, Amilcar, De Souza, Antônio P., de Oliveira, Kleber T., Souza, Larissa M., Inada, Natalia M., Bagnato, Vanderlei S., Oliveira, Samuel L., Caires, Anderson R. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9457702/
https://www.ncbi.nlm.nih.gov/pubmed/36080466
http://dx.doi.org/10.3390/molecules27175699
Descripción
Sumario:This study reports curcumin as an efficient photolarvicide against Aedes aegypti larvae under natural light illumination. Larval mortality and pupal formation were monitored daily for 21 days under simulated field conditions. In a sucrose-containing formulation, a lethal time 50 ([Formula: see text]) of 3 days was found using curcumin at 4.6 mg L(−1). This formulation promoted no larval toxicity in the absence of illumination, and sucrose alone did not induce larval phototoxicity. The photodegradation byproducts (intermediates) of curcumin were determined and the photodegradation mechanisms proposed. Intermediates with m/z 194, 278, and 370 were found and characterized using LC-MS. The ecotoxicity of the byproducts on non-target organisms (Daphnia, fish, and green algae) indicates that the intermediates do not exhibit any destructive potential for aquatic organisms. The results of photodegradation and ecotoxicity suggest that curcumin is environmentally safe for non-target organisms and, therefore, can be considered for population control of Ae. aegypti.