Synthesis and Antifungal Activity of Chimonanthus praecox Derivatives

To search for efficient agricultural antifungal lead compounds, 39 Chimonanthus praecox derivatives were designed, synthesized, and evaluated for their antifungal activities. The structures of target compounds were fully characterized by (1)H NMR, (13)C NMR, and MS spectra. The preliminary bioassays...

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Autores principales: Chen, Jinfeng, Yang, Yimou, Zhou, Yujie, Wei, Yang, Zhu, Rui, Zheng, Shaojun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9457717/
https://www.ncbi.nlm.nih.gov/pubmed/36080337
http://dx.doi.org/10.3390/molecules27175570
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author Chen, Jinfeng
Yang, Yimou
Zhou, Yujie
Wei, Yang
Zhu, Rui
Zheng, Shaojun
author_facet Chen, Jinfeng
Yang, Yimou
Zhou, Yujie
Wei, Yang
Zhu, Rui
Zheng, Shaojun
author_sort Chen, Jinfeng
collection PubMed
description To search for efficient agricultural antifungal lead compounds, 39 Chimonanthus praecox derivatives were designed, synthesized, and evaluated for their antifungal activities. The structures of target compounds were fully characterized by (1)H NMR, (13)C NMR, and MS spectra. The preliminary bioassays revealed that some compounds exhibited excellent antifungal activities in vitro. For example, the minimum inhibitory concentration (MIC) of compound b15 against Phytophthora infestans was 1.95 µg mL(−1), and the minimum inhibitory concentration (MIC) of compound b17 against Sclerotinia sclerotiorum was 1.95 µg mL(−1). Therefore, compounds b15 and b17 were identified as the most promising candidates for further study.
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spelling pubmed-94577172022-09-09 Synthesis and Antifungal Activity of Chimonanthus praecox Derivatives Chen, Jinfeng Yang, Yimou Zhou, Yujie Wei, Yang Zhu, Rui Zheng, Shaojun Molecules Article To search for efficient agricultural antifungal lead compounds, 39 Chimonanthus praecox derivatives were designed, synthesized, and evaluated for their antifungal activities. The structures of target compounds were fully characterized by (1)H NMR, (13)C NMR, and MS spectra. The preliminary bioassays revealed that some compounds exhibited excellent antifungal activities in vitro. For example, the minimum inhibitory concentration (MIC) of compound b15 against Phytophthora infestans was 1.95 µg mL(−1), and the minimum inhibitory concentration (MIC) of compound b17 against Sclerotinia sclerotiorum was 1.95 µg mL(−1). Therefore, compounds b15 and b17 were identified as the most promising candidates for further study. MDPI 2022-08-30 /pmc/articles/PMC9457717/ /pubmed/36080337 http://dx.doi.org/10.3390/molecules27175570 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chen, Jinfeng
Yang, Yimou
Zhou, Yujie
Wei, Yang
Zhu, Rui
Zheng, Shaojun
Synthesis and Antifungal Activity of Chimonanthus praecox Derivatives
title Synthesis and Antifungal Activity of Chimonanthus praecox Derivatives
title_full Synthesis and Antifungal Activity of Chimonanthus praecox Derivatives
title_fullStr Synthesis and Antifungal Activity of Chimonanthus praecox Derivatives
title_full_unstemmed Synthesis and Antifungal Activity of Chimonanthus praecox Derivatives
title_short Synthesis and Antifungal Activity of Chimonanthus praecox Derivatives
title_sort synthesis and antifungal activity of chimonanthus praecox derivatives
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9457717/
https://www.ncbi.nlm.nih.gov/pubmed/36080337
http://dx.doi.org/10.3390/molecules27175570
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