Cargando…

Small Molecule Inhibitors for Hepatocellular Carcinoma: Advances and Challenges

HIGHLIGHTS: Multi tyrosine kinase inhibitors licensed for HCC treatment. Multi kinase inhibitors not licensed for HCC treatment. Inhibitors of Growth Factor Receptors. Small molecules acting as immunomodulators. Small molecules inhibiting crucial HCC pathways. Small molecules targeting various molec...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kamal, Monica A., Mandour, Yasmine M., Abd El-Aziz, Mostafa K., Stein, Ulrike, El Tayebi, Hend M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9457820/ https://www.ncbi.nlm.nih.gov/pubmed/36080304 http://dx.doi.org/10.3390/molecules27175537

Ejemplares similares

Virtual Screening and Biological Evaluation of Potential PD-1/PD-L1 Immune Checkpoint Inhibitors as Anti-Hepatocellular Carcinoma Agents
por: Kamal, Monica A., et al.
Publicado: (2023)

Genetic Heterogeneity, Therapeutic Hurdle Confronting Sorafenib and Immune Checkpoint Inhibitors in Hepatocellular Carcinoma
por: Atwa, Sara M., et al.
Publicado: (2021)

CXCR2 Small-Molecule Antagonist Combats Chemoresistance and Enhances Immunotherapy in Triple-Negative Breast Cancer
por: Ghallab, Alaa M., et al.
Publicado: (2022)

The Monocyte, a Maestro in the Tumor Microenvironment (TME) of Breast Cancer
por: Amer, Hoda T., et al.
Publicado: (2022)

Rs205764 and rs547311 in linc00513 may influence treatment responses in multiple sclerosis patients: A pharmacogenomics Egyptian study
por: Amin, Nada Sherif, et al.
Publicado: (2023)

Survivin Small Molecules Inhibitors: Recent Advances and Challenges
por: Albadari, Najah, et al.
Publicado: (2023)

Thymoquinone: A Tie-Breaker in SARS-CoV2-Infected Cancer Patients?
por: Elgohary, Sawsan, et al.
Publicado: (2021)

Thymoquinone, a Novel Multi-Strike Inhibitor of Pro-Tumorigenic Breast Cancer (BC) Markers: CALR, NLRP3 Pathway and sPD-L1 in PBMCs of HR+ and TNBC Patients
por: Elgohary, Sawsan, et al.
Publicado: (2023)

Small-molecule inhibitors of kinases in breast cancer therapy: recent advances, opportunities, and challenges
por: Bansal, Isha, et al.
Publicado: (2023)

Recent Advancements in the Development of Anti-Breast Cancer Synthetic Small Molecules
por: Elkaeed, Eslam B., et al.
Publicado: (2021)

Advances in small molecule inhibitors for treatment of psoriasis
por: Chen, Wen-Juan, et al.
Publicado: (2021)

Predictors for hepatocellular carcinoma recurrence after microwave ablation
por: Moteleub, Hend Naguib Abd El, et al.
Publicado: (2020)

Scavenging the hidden impacts of non-coding RNAs in multiple sclerosis
por: Elkhodiry, Aya A., et al.
Publicado: (2021)

Behind the curtain of non-coding RNAs; long non-coding RNAs regulating hepatocarcinogenesis
por: El Khodiry, Aya, et al.
Publicado: (2018)

Small molecule tyrosine kinase inhibitors in pancreatic cancer
por: Gupta, Sachin, et al.
Publicado: (2008)

Immune Checkpoint Inhibitors for Unresectable Hepatocellular Carcinoma
por: Abd El Aziz, Mohamed A., et al.
Publicado: (2020)

Molecular Characteristics of RAGE and Advances in Small-Molecule Inhibitors
por: Kim, Hyeon Jin, et al.
Publicado: (2021)

Recent Advances in Small Molecule Inhibitors for the Treatment of Osteoarthritis
por: Lin, Jianjing, et al.
Publicado: (2023)

Pivotal role of long non-coding ribonucleic acid-X-inactive specific transcript in regulating immune checkpoint programmed death ligand 1 through a shared pathway between miR-194-5p and miR-155-5p in hepatocellular carcinoma
por: Atwa, Sara M, et al.
Publicado: (2020)

Synthesis and Characterization of New Polymeric Ionic Liquids as Corrosion Inhibitors for Carbon Steel in a Corrosive Medium: Experimental, Spectral, and Theoretical Studies
por: Asfour, Hend, et al.
Publicado: (2023)

GPI-AP: Unraveling a New Class of Malignancy Mediators and Potential Immunotherapy Targets
por: Hussein, Nada H., et al.
Publicado: (2020)

A cutting-edge immunomodulatory interlinkage between HOTAIR and MALAT1 in tumor-associated macrophages in breast cancer: A personalized immunotherapeutic approach
por: Amer, Hoda T., et al.
Publicado: (2022)

5-Arylidene-1,3-dialkylbarbituric acid derivatives as efficient corrosion inhibitors for carbon steel in molar hydrochloric acid solution
por: Abd El-Khalek, Khaled M., et al.
Publicado: (2022)

Cost-effectiveness analysis of different devices used for the closure of small-to-medium-sized patent ductus arteriosus in pediatric patients
por: El-Saiedi, Sonia A, et al.
Publicado: (2017)

Small molecules in targeted cancer therapy: advances, challenges, and future perspectives
por: Zhong, Lei, et al.
Publicado: (2021)

XIST and TSIX: Novel Cancer Immune Biomarkers in PD-L1-Overexpressing Breast Cancer Patients
por: Salama, Esraa A., et al.
Publicado: (2020)

MicroRNA‑155 modulation of CD8(+) T‑cell activity personalizes response to disease‑modifying therapies of patients with relapsing‑remitting multiple sclerosis
por: Elkhodiry, Aya A., et al.
Publicado: (2023)

Small molecule, big advance against Marburg virus
por: Harrington, Monica
Publicado: (2014)

Recent advances in the discovery of small-molecule inhibitors of HIV-1 integrase
por: Choi, Eungi, et al.
Publicado: (2018)

Editorial: Immunotherapy and small molecule inhibitors as combinational cancer therapeutics
por: Khan, Mohd Wajid Ali, et al.
Publicado: (2023)

Small Molecule Substrate Phosphorylation Site Inhibitors of Protein Kinases: Approaches and Challenges
por: Breen, Meghan E., et al.
Publicado: (2014)

Small Molecule Inhibitors of Interferon‐Induced JAK‐STAT Signalling
por: Thoidingjam, Leishemba K., et al.
Publicado: (2022)

Methylation in MIRLET7A3 Gene Induces the Expression of IGF-II and Its mRNA Binding Proteins IGF2BP-2 and 3 in Hepatocellular Carcinoma
por: Waly, Amr A., et al.
Publicado: (2019)

Gastrointestinal stromal tumors of the small intestine: the challenge of diagnosis and the outcome of management
por: Hamed, Hosam, et al.
Publicado: (2023)

Cytotoxic activity of the novel small molecule AKT inhibitor SC66 in hepatocellular carcinoma cells
por: Cusimano, Antonella, et al.
Publicado: (2014)

HER2 therapy. Small molecule HER-2 tyrosine kinase inhibitors
por: Spector, Neil, et al.
Publicado: (2007)

Challenges of advanced hepatocellular carcinoma
por: Colagrande, Stefano, et al.
Publicado: (2016)

Biologics and oral small‐molecule inhibitors for treatment of pediatric atopic dermatitis: Opportunities and challenges
por: Zhao, Anqi, et al.
Publicado: (2023)

miR-34a: Multiple Opposing Targets and One Destiny in Hepatocellular Carcinoma
por: Yacoub, Radwa Alaa, et al.
Publicado: (2016)

The Pathological Evaluation of Autophagy-Related Protein (LC3B) and Its Association with the Infiltration of Immune Cells in Glioma
por: Mostafa Mohammed, Sara, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_asl3jurqg2pm88j62jlvjv2ika