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Evaluating the Biodegradation of Veterinary Antibiotics Using Kinetics Model and Response Surface Methodology
The inappropriate use and indiscriminate disposal of antibiotics has become a menace worldwide. The incomplete removal of these contaminants from wastewater treatment plants has also contributed to this. This study presents the biodegradation of two veterinary antibiotics; ciprofloxacin (CIP) and en...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9457998/ https://www.ncbi.nlm.nih.gov/pubmed/36080173 http://dx.doi.org/10.3390/molecules27175402 |
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author | Chollom, Martha Noro Bakare, Babatunde Femi Rathilal, Sudesh Tetteh, Emmanuel Kweinor |
author_facet | Chollom, Martha Noro Bakare, Babatunde Femi Rathilal, Sudesh Tetteh, Emmanuel Kweinor |
author_sort | Chollom, Martha Noro |
collection | PubMed |
description | The inappropriate use and indiscriminate disposal of antibiotics has become a menace worldwide. The incomplete removal of these contaminants from wastewater treatment plants has also contributed to this. This study presents the biodegradation of two veterinary antibiotics; ciprofloxacin (CIP) and enrofloxacin (ENRO). Kinetics models were explored to understand the dynamics of biodegradation in an anaerobic digestion process. This was carried out in batch reactors under various operating conditions: pH, organic loading rate (OLR), and antibiotic concentration. The influence of the parameters was investigated using a response surface methodology (RSM) based on the Box–Behnken experimental design of 15 runs. The data obtained were fitted on a polynomial function model. OLR and pH exhibited a synergistic and antagonistic effect in the response models developed, with a high correlation regression coefficient (R(2); 0.9834–0.9875) close to 1 at a 95% confidence level. The optimum conditions obtained from the RSM numerical optimization were pH (6), OLR (2 kgCOD·m(−3)·days(−1)), and an antibiotic concentration of 75%, which gave the removal of CIP, ENRO, and COD, respectively, as 80%, 83%, and 73% at a desirability function of 85%. The kinetics study shows that the biodegradation of antibiotics was well fitted on a first-order model (R(2); 0.9885–0.9978) with rate constants ranging from 0.0695 to 0.96 days(−1). |
format | Online Article Text |
id | pubmed-9457998 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94579982022-09-09 Evaluating the Biodegradation of Veterinary Antibiotics Using Kinetics Model and Response Surface Methodology Chollom, Martha Noro Bakare, Babatunde Femi Rathilal, Sudesh Tetteh, Emmanuel Kweinor Molecules Article The inappropriate use and indiscriminate disposal of antibiotics has become a menace worldwide. The incomplete removal of these contaminants from wastewater treatment plants has also contributed to this. This study presents the biodegradation of two veterinary antibiotics; ciprofloxacin (CIP) and enrofloxacin (ENRO). Kinetics models were explored to understand the dynamics of biodegradation in an anaerobic digestion process. This was carried out in batch reactors under various operating conditions: pH, organic loading rate (OLR), and antibiotic concentration. The influence of the parameters was investigated using a response surface methodology (RSM) based on the Box–Behnken experimental design of 15 runs. The data obtained were fitted on a polynomial function model. OLR and pH exhibited a synergistic and antagonistic effect in the response models developed, with a high correlation regression coefficient (R(2); 0.9834–0.9875) close to 1 at a 95% confidence level. The optimum conditions obtained from the RSM numerical optimization were pH (6), OLR (2 kgCOD·m(−3)·days(−1)), and an antibiotic concentration of 75%, which gave the removal of CIP, ENRO, and COD, respectively, as 80%, 83%, and 73% at a desirability function of 85%. The kinetics study shows that the biodegradation of antibiotics was well fitted on a first-order model (R(2); 0.9885–0.9978) with rate constants ranging from 0.0695 to 0.96 days(−1). MDPI 2022-08-24 /pmc/articles/PMC9457998/ /pubmed/36080173 http://dx.doi.org/10.3390/molecules27175402 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Chollom, Martha Noro Bakare, Babatunde Femi Rathilal, Sudesh Tetteh, Emmanuel Kweinor Evaluating the Biodegradation of Veterinary Antibiotics Using Kinetics Model and Response Surface Methodology |
title | Evaluating the Biodegradation of Veterinary Antibiotics Using Kinetics Model and Response Surface Methodology |
title_full | Evaluating the Biodegradation of Veterinary Antibiotics Using Kinetics Model and Response Surface Methodology |
title_fullStr | Evaluating the Biodegradation of Veterinary Antibiotics Using Kinetics Model and Response Surface Methodology |
title_full_unstemmed | Evaluating the Biodegradation of Veterinary Antibiotics Using Kinetics Model and Response Surface Methodology |
title_short | Evaluating the Biodegradation of Veterinary Antibiotics Using Kinetics Model and Response Surface Methodology |
title_sort | evaluating the biodegradation of veterinary antibiotics using kinetics model and response surface methodology |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9457998/ https://www.ncbi.nlm.nih.gov/pubmed/36080173 http://dx.doi.org/10.3390/molecules27175402 |
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