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Evaluating the Biodegradation of Veterinary Antibiotics Using Kinetics Model and Response Surface Methodology

The inappropriate use and indiscriminate disposal of antibiotics has become a menace worldwide. The incomplete removal of these contaminants from wastewater treatment plants has also contributed to this. This study presents the biodegradation of two veterinary antibiotics; ciprofloxacin (CIP) and en...

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Autores principales: Chollom, Martha Noro, Bakare, Babatunde Femi, Rathilal, Sudesh, Tetteh, Emmanuel Kweinor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9457998/
https://www.ncbi.nlm.nih.gov/pubmed/36080173
http://dx.doi.org/10.3390/molecules27175402
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author Chollom, Martha Noro
Bakare, Babatunde Femi
Rathilal, Sudesh
Tetteh, Emmanuel Kweinor
author_facet Chollom, Martha Noro
Bakare, Babatunde Femi
Rathilal, Sudesh
Tetteh, Emmanuel Kweinor
author_sort Chollom, Martha Noro
collection PubMed
description The inappropriate use and indiscriminate disposal of antibiotics has become a menace worldwide. The incomplete removal of these contaminants from wastewater treatment plants has also contributed to this. This study presents the biodegradation of two veterinary antibiotics; ciprofloxacin (CIP) and enrofloxacin (ENRO). Kinetics models were explored to understand the dynamics of biodegradation in an anaerobic digestion process. This was carried out in batch reactors under various operating conditions: pH, organic loading rate (OLR), and antibiotic concentration. The influence of the parameters was investigated using a response surface methodology (RSM) based on the Box–Behnken experimental design of 15 runs. The data obtained were fitted on a polynomial function model. OLR and pH exhibited a synergistic and antagonistic effect in the response models developed, with a high correlation regression coefficient (R(2); 0.9834–0.9875) close to 1 at a 95% confidence level. The optimum conditions obtained from the RSM numerical optimization were pH (6), OLR (2 kgCOD·m(−3)·days(−1)), and an antibiotic concentration of 75%, which gave the removal of CIP, ENRO, and COD, respectively, as 80%, 83%, and 73% at a desirability function of 85%. The kinetics study shows that the biodegradation of antibiotics was well fitted on a first-order model (R(2); 0.9885–0.9978) with rate constants ranging from 0.0695 to 0.96 days(−1).
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spelling pubmed-94579982022-09-09 Evaluating the Biodegradation of Veterinary Antibiotics Using Kinetics Model and Response Surface Methodology Chollom, Martha Noro Bakare, Babatunde Femi Rathilal, Sudesh Tetteh, Emmanuel Kweinor Molecules Article The inappropriate use and indiscriminate disposal of antibiotics has become a menace worldwide. The incomplete removal of these contaminants from wastewater treatment plants has also contributed to this. This study presents the biodegradation of two veterinary antibiotics; ciprofloxacin (CIP) and enrofloxacin (ENRO). Kinetics models were explored to understand the dynamics of biodegradation in an anaerobic digestion process. This was carried out in batch reactors under various operating conditions: pH, organic loading rate (OLR), and antibiotic concentration. The influence of the parameters was investigated using a response surface methodology (RSM) based on the Box–Behnken experimental design of 15 runs. The data obtained were fitted on a polynomial function model. OLR and pH exhibited a synergistic and antagonistic effect in the response models developed, with a high correlation regression coefficient (R(2); 0.9834–0.9875) close to 1 at a 95% confidence level. The optimum conditions obtained from the RSM numerical optimization were pH (6), OLR (2 kgCOD·m(−3)·days(−1)), and an antibiotic concentration of 75%, which gave the removal of CIP, ENRO, and COD, respectively, as 80%, 83%, and 73% at a desirability function of 85%. The kinetics study shows that the biodegradation of antibiotics was well fitted on a first-order model (R(2); 0.9885–0.9978) with rate constants ranging from 0.0695 to 0.96 days(−1). MDPI 2022-08-24 /pmc/articles/PMC9457998/ /pubmed/36080173 http://dx.doi.org/10.3390/molecules27175402 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chollom, Martha Noro
Bakare, Babatunde Femi
Rathilal, Sudesh
Tetteh, Emmanuel Kweinor
Evaluating the Biodegradation of Veterinary Antibiotics Using Kinetics Model and Response Surface Methodology
title Evaluating the Biodegradation of Veterinary Antibiotics Using Kinetics Model and Response Surface Methodology
title_full Evaluating the Biodegradation of Veterinary Antibiotics Using Kinetics Model and Response Surface Methodology
title_fullStr Evaluating the Biodegradation of Veterinary Antibiotics Using Kinetics Model and Response Surface Methodology
title_full_unstemmed Evaluating the Biodegradation of Veterinary Antibiotics Using Kinetics Model and Response Surface Methodology
title_short Evaluating the Biodegradation of Veterinary Antibiotics Using Kinetics Model and Response Surface Methodology
title_sort evaluating the biodegradation of veterinary antibiotics using kinetics model and response surface methodology
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9457998/
https://www.ncbi.nlm.nih.gov/pubmed/36080173
http://dx.doi.org/10.3390/molecules27175402
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