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Lipid Nanoparticles for mRNA Delivery to Enhance Cancer Immunotherapy
Messenger RNA (mRNA) is being developed by researchers as a novel drug for the treatment or prevention of many diseases. However, to enable mRNA to fully exploit its effects in vivo, researchers need to develop safer and more effective mRNA delivery systems that improve mRNA stability and enhance th...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458026/ https://www.ncbi.nlm.nih.gov/pubmed/36080373 http://dx.doi.org/10.3390/molecules27175607 |
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author | Wang, Hong-Li Wang, Zhi-Gang Liu, Shu-Lin |
author_facet | Wang, Hong-Li Wang, Zhi-Gang Liu, Shu-Lin |
author_sort | Wang, Hong-Li |
collection | PubMed |
description | Messenger RNA (mRNA) is being developed by researchers as a novel drug for the treatment or prevention of many diseases. However, to enable mRNA to fully exploit its effects in vivo, researchers need to develop safer and more effective mRNA delivery systems that improve mRNA stability and enhance the ability of cells to take up and release mRNA. To date, lipid nanoparticles are promising nanodrug carriers for tumor therapy, which can significantly improve the immunotherapeutic effects of conventional drugs by modulating mRNA delivery, and have attracted widespread interest in the biomedical field. This review focuses on the delivery of mRNA by lipid nanoparticles for cancer treatment. We summarize some common tumor immunotherapy and mRNA delivery strategies, describe the clinical advantages of lipid nanoparticles for mRNA delivery, and provide an outlook on the current challenges and future developments of this technology. |
format | Online Article Text |
id | pubmed-9458026 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94580262022-09-09 Lipid Nanoparticles for mRNA Delivery to Enhance Cancer Immunotherapy Wang, Hong-Li Wang, Zhi-Gang Liu, Shu-Lin Molecules Review Messenger RNA (mRNA) is being developed by researchers as a novel drug for the treatment or prevention of many diseases. However, to enable mRNA to fully exploit its effects in vivo, researchers need to develop safer and more effective mRNA delivery systems that improve mRNA stability and enhance the ability of cells to take up and release mRNA. To date, lipid nanoparticles are promising nanodrug carriers for tumor therapy, which can significantly improve the immunotherapeutic effects of conventional drugs by modulating mRNA delivery, and have attracted widespread interest in the biomedical field. This review focuses on the delivery of mRNA by lipid nanoparticles for cancer treatment. We summarize some common tumor immunotherapy and mRNA delivery strategies, describe the clinical advantages of lipid nanoparticles for mRNA delivery, and provide an outlook on the current challenges and future developments of this technology. MDPI 2022-08-31 /pmc/articles/PMC9458026/ /pubmed/36080373 http://dx.doi.org/10.3390/molecules27175607 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Wang, Hong-Li Wang, Zhi-Gang Liu, Shu-Lin Lipid Nanoparticles for mRNA Delivery to Enhance Cancer Immunotherapy |
title | Lipid Nanoparticles for mRNA Delivery to Enhance Cancer Immunotherapy |
title_full | Lipid Nanoparticles for mRNA Delivery to Enhance Cancer Immunotherapy |
title_fullStr | Lipid Nanoparticles for mRNA Delivery to Enhance Cancer Immunotherapy |
title_full_unstemmed | Lipid Nanoparticles for mRNA Delivery to Enhance Cancer Immunotherapy |
title_short | Lipid Nanoparticles for mRNA Delivery to Enhance Cancer Immunotherapy |
title_sort | lipid nanoparticles for mrna delivery to enhance cancer immunotherapy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458026/ https://www.ncbi.nlm.nih.gov/pubmed/36080373 http://dx.doi.org/10.3390/molecules27175607 |
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