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Cascade Processes with Micellar Reaction Media: Recent Advances and Future Directions

Reducing the use of solvents is an important aim of green chemistry. Using micelles self-assembled from amphiphilic molecules dispersed in water (considered a green solvent) has facilitated reactions of organic compounds. When performing reactions in micelles, the hydrophobic effect can considerably...

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Autores principales: Tang, Christina, McInnes, Bridget T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458028/
https://www.ncbi.nlm.nih.gov/pubmed/36080376
http://dx.doi.org/10.3390/molecules27175611
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author Tang, Christina
McInnes, Bridget T.
author_facet Tang, Christina
McInnes, Bridget T.
author_sort Tang, Christina
collection PubMed
description Reducing the use of solvents is an important aim of green chemistry. Using micelles self-assembled from amphiphilic molecules dispersed in water (considered a green solvent) has facilitated reactions of organic compounds. When performing reactions in micelles, the hydrophobic effect can considerably accelerate apparent reaction rates, as well as enhance selectivity. Here, we review micellar reaction media and their potential role in sustainable chemical production. The focus of this review is applications of engineered amphiphilic systems for reactions (surface-active ionic liquids, designer surfactants, and block copolymers) as reaction media. Micelles are a versatile platform for performing a large array of organic chemistries using water as the bulk solvent. Building on this foundation, synthetic sequences combining several reaction steps in one pot have been developed. Telescoping multiple reactions can reduce solvent waste by limiting the volume of solvents, as well as eliminating purification processes. Thus, in particular, we review recent advances in “one-pot” multistep reactions achieved using micellar reaction media with potential applications in medicinal chemistry and agrochemistry. Photocatalyzed reactions in micellar reaction media are also discussed. In addition to the use of micelles, we emphasize the process (steps to isolate the product and reuse the catalyst).
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spelling pubmed-94580282022-09-09 Cascade Processes with Micellar Reaction Media: Recent Advances and Future Directions Tang, Christina McInnes, Bridget T. Molecules Review Reducing the use of solvents is an important aim of green chemistry. Using micelles self-assembled from amphiphilic molecules dispersed in water (considered a green solvent) has facilitated reactions of organic compounds. When performing reactions in micelles, the hydrophobic effect can considerably accelerate apparent reaction rates, as well as enhance selectivity. Here, we review micellar reaction media and their potential role in sustainable chemical production. The focus of this review is applications of engineered amphiphilic systems for reactions (surface-active ionic liquids, designer surfactants, and block copolymers) as reaction media. Micelles are a versatile platform for performing a large array of organic chemistries using water as the bulk solvent. Building on this foundation, synthetic sequences combining several reaction steps in one pot have been developed. Telescoping multiple reactions can reduce solvent waste by limiting the volume of solvents, as well as eliminating purification processes. Thus, in particular, we review recent advances in “one-pot” multistep reactions achieved using micellar reaction media with potential applications in medicinal chemistry and agrochemistry. Photocatalyzed reactions in micellar reaction media are also discussed. In addition to the use of micelles, we emphasize the process (steps to isolate the product and reuse the catalyst). MDPI 2022-08-31 /pmc/articles/PMC9458028/ /pubmed/36080376 http://dx.doi.org/10.3390/molecules27175611 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tang, Christina
McInnes, Bridget T.
Cascade Processes with Micellar Reaction Media: Recent Advances and Future Directions
title Cascade Processes with Micellar Reaction Media: Recent Advances and Future Directions
title_full Cascade Processes with Micellar Reaction Media: Recent Advances and Future Directions
title_fullStr Cascade Processes with Micellar Reaction Media: Recent Advances and Future Directions
title_full_unstemmed Cascade Processes with Micellar Reaction Media: Recent Advances and Future Directions
title_short Cascade Processes with Micellar Reaction Media: Recent Advances and Future Directions
title_sort cascade processes with micellar reaction media: recent advances and future directions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458028/
https://www.ncbi.nlm.nih.gov/pubmed/36080376
http://dx.doi.org/10.3390/molecules27175611
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