(131)I-C19 Iodide Radioisotope and Synthetic I-C19 Compounds as K-Ras4B–PDE6δ Inhibitors: A Novel Approach against Colorectal Cancer—Biological Characterization, Biokinetics and Dosimetry

In 40–50% of colorectal cancer (CRC) cases, K-Ras gene mutations occur, which induce the expression of the K-Ras4B oncogenic isoform. K-Ras4B is transported by phosphodiesterase-6δ (PDE6δ) to the plasma membrane, where the K-Ras4B–PDE6δ complex dissociates and K-Ras4B, coupled to the plasma membrane...

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Detalles Bibliográficos
Autores principales: Cruz-Nova, Pedro, Ocampo-García, Blanca, Carrión-Estrada, Dayan Andrea, Briseño-Diaz, Paola, Ferro-Flores, Guillermina, Jiménez-Mancilla, Nallely, Correa-Basurto, José, Bello, Martiniano, Vega-Loyo, Libia, Thompson-Bonilla, María del Rocío, Hernández-Rivas, Rosaura, Vargas, Miguel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458062/
https://www.ncbi.nlm.nih.gov/pubmed/36080216
http://dx.doi.org/10.3390/molecules27175446

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