Cargando…

BCI-215, a Dual-Specificity Phosphatase Inhibitor, Reduces UVB-Induced Pigmentation in Human Skin by Activating Mitogen-Activated Protein Kinase Pathways

Background: The dysregulation of melanin production causes skin-disfiguring ultraviolet (UV)-associated hyperpigmented spots. Previously, we found that the activation of c-Jun N-terminal kinase (JNK), a mitogen-activated protein kinase (MAPK), inhibited melanogenesis. Methods: We selected BCI-215 as...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Jeong Hyeon, Choi, Myoung Eun, An, Hongchan, Moon, Ju Won, Yeo, Hye Jin, Song, Youngsup, Chang, Sung Eun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458123/ https://www.ncbi.nlm.nih.gov/pubmed/36080217 http://dx.doi.org/10.3390/molecules27175449

Ejemplares similares

Dual-Specificity Phosphatase 10 Controls Brown Adipocyte Differentiation by Modulating the Phosphorylation of P38 Mitogen-Activated Protein Kinase
por: Choi, Hye-Ryung, et al.
Publicado: (2013)

Mitogen-Activated Protein Kinase Phosphatases: No Longer Undruggable?
por: Shillingford, Shanelle R., et al.
Publicado: (2023)

The regulation of oncogenic Ras/ERK signalling by dual-specificity mitogen activated protein kinase phosphatases (MKPs)
por: Kidger, Andrew M., et al.
Publicado: (2016)

Is Mitogen‐Activated Protein Kinase Phosphatase 5 a Solution to the Puzzle of the Mitogen‐Activated Protein Kinase Signal in Steatohepatitis?
por: Miura, Kouichi, et al.
Publicado: (2019)

Mitogen-Activated Protein Kinases and Mitogen Kinase Phosphatase 1: A Critical Interplay in Macrophage Biology
por: Lloberas, Jorge, et al.
Publicado: (2016)

Saponins of Korean Red Ginseng May Protect Human Skin from Adipokine-Associated Inflammation and Pigmentation Resulting from Particulate Matter Exposure
por: Moon, Ik Jun, et al.
Publicado: (2022)

Sirtuin 2 aggravates postischemic liver injury by deacetylating mitogen‐activated protein kinase phosphatase‐1
por: Wang, Jie, et al.
Publicado: (2016)

Safflower Seed Oil and Its Active Compound Acacetin Inhibit UVB-Induced Skin Photoaging
por: Jeong, Eun Hee, et al.
Publicado: (2020)

Guanine Deaminase in Human Epidermal Keratinocytes Contributes to Skin Pigmentation
por: Jung, Joon Min, et al.
Publicado: (2020)

Radiofrequency Irradiation Attenuated UVB-Induced Skin Pigmentation by Modulating ATP Release and CD39 Expression
por: Byun, Kyung-A, et al.
Publicado: (2023)

The Novel PPAR α/γ Dual Agonist MHY 966 Modulates UVB–Induced Skin Inflammation by Inhibiting NF-κB Activity
por: Park, Min Hi, et al.
Publicado: (2013)

Dual role of SIRT1 in UVB-induced skin tumorigenesis
por: Ming, Mei, et al.
Publicado: (2014)

A novel anti-mycobacterial function of mitogen-activated protein kinase phosphatase-1
por: Cheung, Benny KW, et al.
Publicado: (2009)

Obesity Increases Mitogen-Activated Protein Kinase Phosphatase-3 Levels in the Hypothalamus of Mice
por: Rodrigues, Bárbara de A., et al.
Publicado: (2017)

Mitogen-Activated Protein Kinase Phosphatases (MKPs) in Fungal Signaling: Conservation, Function, and Regulation
por: González-Rubio, Gema, et al.
Publicado: (2019)

Dual-specificity Phosphatase 1 Deficiency Induces Endometrioid Adenocarcinoma Progression via Activation of Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase Pathway
por: Yang, Yuan, et al.
Publicado: (2016)

EEG dataset and OpenBMI toolbox for three BCI paradigms: an investigation into BCI illiteracy
por: Lee, Min-Ho, et al.
Publicado: (2019)

Swertiajaponin inhibits skin pigmentation by dual mechanisms to suppress tyrosinase
por: Lee, Bonggi, et al.
Publicado: (2017)

Acetylation of mitogen-activated protein kinase phosphatase-1 inhibits Toll-like receptor signaling
por: Cao, Wangsen, et al.
Publicado: (2008)

Biphasic Regulation of Mitogen-Activated Protein Kinase Phosphatase 3 in Hypoxic Colon Cancer Cells
por: Kim, Hong Seok, et al.
Publicado: (2021)

Carvedilol, an Adrenergic Blocker, Suppresses Melanin Synthesis by Inhibiting the cAMP/CREB Signaling Pathway in Human Melanocytes and Ex Vivo Human Skin Culture
por: Choi, Myoung Eun, et al.
Publicado: (2020)

PTEN Reduced UVB-Mediated Apoptosis in Retinal Pigment Epithelium Cells
por: He, Jia, et al.
Publicado: (2017)

BCI, an inhibitor of the DUSP1 and DUSP6 dual specificity phosphatases, enhances P2X7 receptor expression in neuroblastoma cells
por: Benito-León, María, et al.
Publicado: (2022)

Metabolic Analyses and Evaluation of Antioxidant Activity in Purple Kohlrabi Sprouts after Exposed to UVB Radiation
por: Yeo, Hyeon Ji, et al.
Publicado: (2022)

Caviar Extract and Its Constituent DHA Inhibits UVB-Irradiated Skin Aging by Inducing Adiponectin Production
por: Lee, Kyung-Eun, et al.
Publicado: (2020)

Adiponectin Increases Skeletal Muscle Mitochondrial Biogenesis by Suppressing Mitogen-Activated Protein Kinase Phosphatase-1
por: Qiao, Liping, et al.
Publicado: (2012)

Phosphatase-Dependent Regulation of Epithelial Mitogen-Activated Protein Kinase Responses to Toxin-Induced Membrane Pores
por: Aguilar, Jorge L., et al.
Publicado: (2009)

Interaction of Kinase-Interaction-Motif Protein Tyrosine Phosphatases with the Mitogen-Activated Protein Kinase ERK2
por: Francis, Dana M., et al.
Publicado: (2014)

Role of mitogen-activated protein kinase phosphatase-1 in corticosteroid insensitivity of chronic oxidant lung injury
por: Pinart, Mariona, et al.
Publicado: (2014)

Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1) accelerates progressive hearing loss
por: Celaya, Adelaida M, et al.
Publicado: (2019)

Mitogen activated protein kinases (MAPK) and protein phosphatases are involved in Aspergillus fumigatus adhesion and biofilm formation
por: Manfiolli, Adriana Oliveira, et al.
Publicado: (2018)

A new model to investigate UVB-induced cellular senescence and pigmentation in melanocytes
por: Martic, Ines, et al.
Publicado: (2020)

Bacterially Converted Oat Active Ingredients Enhances Antioxidative and Anti-UVB Photoaging Activities
por: Lee, Jennifer K., et al.
Publicado: (2022)

Suppression of Pax3–MITF-M Axis Protects from UVB-Induced Skin Pigmentation by Tetrahydroquinoline Carboxamide
por: Choi, Yong-Pyo, et al.
Publicado: (2020)

Effect of Fish Bone Bioactive Peptides on Oxidative, Inflammatory and Pigmentation Processes Triggered by UVB Irradiation in Skin Cells
por: Iosageanu, Andreea, et al.
Publicado: (2021)

A large scale screening study with a SMR-based BCI: Categorization of BCI users and differences in their SMR activity
por: Sannelli, Claudia, et al.
Publicado: (2019)

The Hybrid BCI
por: Pfurtscheller, Gert, et al.
Publicado: (2010)

A Conserved Non-Canonical Docking Mechanism Regulates the Binding of Dual Specificity Phosphatases to Cell Integrity Mitogen-Activated Protein Kinases (MAPKs) in Budding and Fission Yeasts
por: Sacristán-Reviriego, Almudena, et al.
Publicado: (2014)

Mitogen-Activated Protein Kinase Phosphatase 3 (MKP-3)–Deficient Mice Are Resistant to Diet-Induced Obesity
por: Feng, Bin, et al.
Publicado: (2014)

A role for mitogen-activated protein kinase phosphatase 1 (MKP1) in neural cell development and survival
por: Toulouse, André, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_p4hiib13nmek2p3ien0h9dpdt0