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Marine Bacterial Dextranases: Fundamentals and Applications
Dextran, a renewable hydrophilic polysaccharide, is nontoxic, highly stable but intrinsically biodegradable. The α-1, 6 glycosidic bonds in dextran are attacked by dextranase (E.C. 3.2.1.11) which is an inducible enzyme. Dextranase finds many applications such as, in sugar industry, in the productio...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458216/ https://www.ncbi.nlm.nih.gov/pubmed/36080300 http://dx.doi.org/10.3390/molecules27175533 |
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author | Barzkar, Noora Babich, Olga Das, Rakesh Sukhikh, Stanislav Tamadoni Jahromi, Saeid Sohail, Muhammad |
author_facet | Barzkar, Noora Babich, Olga Das, Rakesh Sukhikh, Stanislav Tamadoni Jahromi, Saeid Sohail, Muhammad |
author_sort | Barzkar, Noora |
collection | PubMed |
description | Dextran, a renewable hydrophilic polysaccharide, is nontoxic, highly stable but intrinsically biodegradable. The α-1, 6 glycosidic bonds in dextran are attacked by dextranase (E.C. 3.2.1.11) which is an inducible enzyme. Dextranase finds many applications such as, in sugar industry, in the production of human plasma substitutes, and for the treatment and prevention of dental plaque. Currently, dextranases are obtained from terrestrial fungi which have longer duration for production but not very tolerant to environmental conditions and have safety concerns. Marine bacteria have been proposed as an alternative source of these enzymes and can provide prospects to overcome these issues. Indeed, marine bacterial dextranases are reportedly more effective and suitable for dental caries prevention and treatment. Here, we focused on properties of dextran, properties of dextran—hydrolyzing enzymes, particularly from marine sources and the biochemical features of these enzymes. Lastly the potential use of these marine bacterial dextranase to remove dental plaque has been discussed. The review covers dextranase-producing bacteria isolated from shrimp, fish, algae, sea slit, and sea water, as well as from macro- and micro fungi and other microorganisms. It is common knowledge that dextranase is used in the sugar industry; produced as a result of hydrolysis by dextranase and have prebiotic properties which influence the consistency and texture of food products. In medicine, dextranases are used to make blood substitutes. In addition, dextranase is used to produce low molecular weight dextran and cytotoxic dextran. Furthermore, dextranase is used to enhance antibiotic activity in endocarditis. It has been established that dextranase from marine bacteria is the most preferable for removing plaque, as it has a high enzymatic activity. This study lays the groundwork for the future design and development of different oral care products, based on enzymes derived from marine bacteria. |
format | Online Article Text |
id | pubmed-9458216 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94582162022-09-09 Marine Bacterial Dextranases: Fundamentals and Applications Barzkar, Noora Babich, Olga Das, Rakesh Sukhikh, Stanislav Tamadoni Jahromi, Saeid Sohail, Muhammad Molecules Review Dextran, a renewable hydrophilic polysaccharide, is nontoxic, highly stable but intrinsically biodegradable. The α-1, 6 glycosidic bonds in dextran are attacked by dextranase (E.C. 3.2.1.11) which is an inducible enzyme. Dextranase finds many applications such as, in sugar industry, in the production of human plasma substitutes, and for the treatment and prevention of dental plaque. Currently, dextranases are obtained from terrestrial fungi which have longer duration for production but not very tolerant to environmental conditions and have safety concerns. Marine bacteria have been proposed as an alternative source of these enzymes and can provide prospects to overcome these issues. Indeed, marine bacterial dextranases are reportedly more effective and suitable for dental caries prevention and treatment. Here, we focused on properties of dextran, properties of dextran—hydrolyzing enzymes, particularly from marine sources and the biochemical features of these enzymes. Lastly the potential use of these marine bacterial dextranase to remove dental plaque has been discussed. The review covers dextranase-producing bacteria isolated from shrimp, fish, algae, sea slit, and sea water, as well as from macro- and micro fungi and other microorganisms. It is common knowledge that dextranase is used in the sugar industry; produced as a result of hydrolysis by dextranase and have prebiotic properties which influence the consistency and texture of food products. In medicine, dextranases are used to make blood substitutes. In addition, dextranase is used to produce low molecular weight dextran and cytotoxic dextran. Furthermore, dextranase is used to enhance antibiotic activity in endocarditis. It has been established that dextranase from marine bacteria is the most preferable for removing plaque, as it has a high enzymatic activity. This study lays the groundwork for the future design and development of different oral care products, based on enzymes derived from marine bacteria. MDPI 2022-08-28 /pmc/articles/PMC9458216/ /pubmed/36080300 http://dx.doi.org/10.3390/molecules27175533 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Barzkar, Noora Babich, Olga Das, Rakesh Sukhikh, Stanislav Tamadoni Jahromi, Saeid Sohail, Muhammad Marine Bacterial Dextranases: Fundamentals and Applications |
title | Marine Bacterial Dextranases: Fundamentals and Applications |
title_full | Marine Bacterial Dextranases: Fundamentals and Applications |
title_fullStr | Marine Bacterial Dextranases: Fundamentals and Applications |
title_full_unstemmed | Marine Bacterial Dextranases: Fundamentals and Applications |
title_short | Marine Bacterial Dextranases: Fundamentals and Applications |
title_sort | marine bacterial dextranases: fundamentals and applications |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458216/ https://www.ncbi.nlm.nih.gov/pubmed/36080300 http://dx.doi.org/10.3390/molecules27175533 |
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