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Graft and Patient Outcomes of Kidney Transplant Tourism: A Single-Center Experience

Background  The supply-demand mismatch between organ donor and patient waiting for transplant has led to the growth of transplant tourism. This type of transplant is considered unethical and illegal, as it is usually performed in poor environments and carries a higher risk of infectious, vascular, a...

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Autores principales: Altheaby, Abdulrahman, Owaidah, Kenana, Alotaibi, Aljowharah, Salem, Rahaf, Algain, Rihaf, Alotaibi, Areij, Alnasrullah, Ahmad, Shaheen, Mohammed F., Tawhari, Mohammed, Abdulgadir, Mohamad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Thieme Medical and Scientific Publishers Pvt. Ltd. 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458345/
https://www.ncbi.nlm.nih.gov/pubmed/36092382
http://dx.doi.org/10.1055/s-0042-1750715
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author Altheaby, Abdulrahman
Owaidah, Kenana
Alotaibi, Aljowharah
Salem, Rahaf
Algain, Rihaf
Alotaibi, Areij
Alnasrullah, Ahmad
Shaheen, Mohammed F.
Tawhari, Mohammed
Abdulgadir, Mohamad
author_facet Altheaby, Abdulrahman
Owaidah, Kenana
Alotaibi, Aljowharah
Salem, Rahaf
Algain, Rihaf
Alotaibi, Areij
Alnasrullah, Ahmad
Shaheen, Mohammed F.
Tawhari, Mohammed
Abdulgadir, Mohamad
author_sort Altheaby, Abdulrahman
collection PubMed
description Background  The supply-demand mismatch between organ donor and patient waiting for transplant has led to the growth of transplant tourism. This type of transplant is considered unethical and illegal, as it is usually performed in poor environments and carries a higher risk of infectious, vascular, and immunological complications. Methods  In this single-centered retrospective cohort study, we compared patients who underwent transplant tourism to patients who were transplanted locally and followed up in our hospital from January 2015 to December 2018. Result  A total of 254 local transplants and 60 patients from the transplant tourism group were included. Transplant tourism recipients were younger otherwise both groups were similar in gender, body mass index, diabetes, and hypertension. Recipients in the transplant tourism group had a significantly higher rate of delayed graft function (18.3% vs. 6.3%, p 0.005), acute rejection (40% vs. 7.9%, p  < 0.001), and higher posttransplant infection in general. With more urological complications and higher graft failure at 3-years' follow-up (11.7% vs. 0.8%, p  < 0.001). Conclusion  Transplant tourism is associated with a higher risk of infection and poor graft outcomes. Extra efforts are required to cut down transplant tourism by educating patients about its clinical risk and ethical considerations. In addition, measures to increase the number of deceased donor pool to provide a better alternative options for patients are essential.
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spelling pubmed-94583452022-09-09 Graft and Patient Outcomes of Kidney Transplant Tourism: A Single-Center Experience Altheaby, Abdulrahman Owaidah, Kenana Alotaibi, Aljowharah Salem, Rahaf Algain, Rihaf Alotaibi, Areij Alnasrullah, Ahmad Shaheen, Mohammed F. Tawhari, Mohammed Abdulgadir, Mohamad Avicenna J Med Background  The supply-demand mismatch between organ donor and patient waiting for transplant has led to the growth of transplant tourism. This type of transplant is considered unethical and illegal, as it is usually performed in poor environments and carries a higher risk of infectious, vascular, and immunological complications. Methods  In this single-centered retrospective cohort study, we compared patients who underwent transplant tourism to patients who were transplanted locally and followed up in our hospital from January 2015 to December 2018. Result  A total of 254 local transplants and 60 patients from the transplant tourism group were included. Transplant tourism recipients were younger otherwise both groups were similar in gender, body mass index, diabetes, and hypertension. Recipients in the transplant tourism group had a significantly higher rate of delayed graft function (18.3% vs. 6.3%, p 0.005), acute rejection (40% vs. 7.9%, p  < 0.001), and higher posttransplant infection in general. With more urological complications and higher graft failure at 3-years' follow-up (11.7% vs. 0.8%, p  < 0.001). Conclusion  Transplant tourism is associated with a higher risk of infection and poor graft outcomes. Extra efforts are required to cut down transplant tourism by educating patients about its clinical risk and ethical considerations. In addition, measures to increase the number of deceased donor pool to provide a better alternative options for patients are essential. Thieme Medical and Scientific Publishers Pvt. Ltd. 2022-08-16 /pmc/articles/PMC9458345/ /pubmed/36092382 http://dx.doi.org/10.1055/s-0042-1750715 Text en Avicenna Journal of Medicine. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.
spellingShingle Altheaby, Abdulrahman
Owaidah, Kenana
Alotaibi, Aljowharah
Salem, Rahaf
Algain, Rihaf
Alotaibi, Areij
Alnasrullah, Ahmad
Shaheen, Mohammed F.
Tawhari, Mohammed
Abdulgadir, Mohamad
Graft and Patient Outcomes of Kidney Transplant Tourism: A Single-Center Experience
title Graft and Patient Outcomes of Kidney Transplant Tourism: A Single-Center Experience
title_full Graft and Patient Outcomes of Kidney Transplant Tourism: A Single-Center Experience
title_fullStr Graft and Patient Outcomes of Kidney Transplant Tourism: A Single-Center Experience
title_full_unstemmed Graft and Patient Outcomes of Kidney Transplant Tourism: A Single-Center Experience
title_short Graft and Patient Outcomes of Kidney Transplant Tourism: A Single-Center Experience
title_sort graft and patient outcomes of kidney transplant tourism: a single-center experience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458345/
https://www.ncbi.nlm.nih.gov/pubmed/36092382
http://dx.doi.org/10.1055/s-0042-1750715
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