Chemically targeting the redox switch in AP1 transcription factor ΔFOSB

The AP1 transcription factor ΔFOSB, a splice variant of FOSB, accumulates in the brain in response to chronic insults such as exposure to drugs of abuse, depression, Alzheimer's disease and tardive dyskinesias, and mediates subsequent long-term neuroadaptations. ΔFOSB forms heterodimers with ot...

Descripción completa

Detalles Bibliográficos
Autores principales: Kumar, Ashwani, Aglyamova, Galina, Yim, Yun Young, Bailey, Aaron O, Lynch, Haley M, Powell, Reid T, Nguyen, Nghi D, Rosenthal, Zachary, Zhao, Wen-Ning, Li, Yi, Chen, Jianping, Fan, Shanghua, Lee, Hubert, Russell, William K, Stephan, Clifford, Robison, Alfred J, Haggarty, Stephen J, Nestler, Eric J, Zhou, Jia, Machius, Mischa, Rudenko, Gabby
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458432/
https://www.ncbi.nlm.nih.gov/pubmed/36039764
http://dx.doi.org/10.1093/nar/gkac710

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458432/
https://www.ncbi.nlm.nih.gov/pubmed/36039764
http://dx.doi.org/10.1093/nar/gkac710

Ejemplares similares