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Chemically targeting the redox switch in AP1 transcription factor ΔFOSB

The AP1 transcription factor ΔFOSB, a splice variant of FOSB, accumulates in the brain in response to chronic insults such as exposure to drugs of abuse, depression, Alzheimer's disease and tardive dyskinesias, and mediates subsequent long-term neuroadaptations. ΔFOSB forms heterodimers with ot...

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Detalles Bibliográficos
Autores principales:	Kumar, Ashwani, Aglyamova, Galina, Yim, Yun Young, Bailey, Aaron O, Lynch, Haley M, Powell, Reid T, Nguyen, Nghi D, Rosenthal, Zachary, Zhao, Wen-Ning, Li, Yi, Chen, Jianping, Fan, Shanghua, Lee, Hubert, Russell, William K, Stephan, Clifford, Robison, Alfred J, Haggarty, Stephen J, Nestler, Eric J, Zhou, Jia, Machius, Mischa, Rudenko, Gabby
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458432/ https://www.ncbi.nlm.nih.gov/pubmed/36039764 http://dx.doi.org/10.1093/nar/gkac710

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