Distinct, opposing functions for CFIm59 and CFIm68 in mRNA alternative polyadenylation of Pten and in the PI3K/Akt signalling cascade

Precise maintenance of PTEN dosage is crucial for tumor suppression across a wide variety of cancers. Post-transcriptional regulation of Pten heavily relies on regulatory elements encoded by its 3′UTR. We previously reported the important diversity of 3′UTR isoforms of Pten mRNAs produced through al...

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Detalles Bibliográficos
Autores principales: Tseng, Hsin-Wei, Mota-Sydor, Anthony, Leventis, Rania, Jovanovic, Predrag, Topisirovic, Ivan, Duchaine, Thomas F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458458/
https://www.ncbi.nlm.nih.gov/pubmed/35993810
http://dx.doi.org/10.1093/nar/gkac704

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