Prevalence of dementia and mild cognitive impairment in indigenous Bolivian forager‐horticulturalists

INTRODUCTION: We evaluated the prevalence of dementia and mild cognitive impairment (MCI) in indigenous Tsimane and Moseten, who lead a subsistence lifestyle. METHODS: Participants from population‐based samples ≥ 60 years of age (n = 623) were assessed using adapted versions of the Modified Mini‐Men...

Descripción completa

Detalles Bibliográficos
Autores principales: Gatz, Margaret, Mack, Wendy J., Chui, Helena C., Law, E. Meng, Barisano, Giuseppe, Sutherland, M. Linda, Sutherland, James D., Eid Rodriguez, Daniel, Quispe Gutierrez, Raul, Copajira Adrian, Juan, Bani Cuata, Jesus, Borenstein, Amy R., Walters, Ellen E., Irimia, Andrei, Rowan, Christopher J., Wann, L. Samuel, Allam, Adel H., Thompson, Randall C., Miyamoto, Michael I., Michalik, David E., Cummings, Daniel K., Seabright, Edmond, Garcia, Angela R., Hooper, Paul L., Kraft, Thomas S., Finch, Caleb E., Thomas, Gregory S., Stieglitz, Jonathan, Trumble, Benjamin C., Gurven, Michael D., Kaplan, Hillard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Featured Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458772/
https://www.ncbi.nlm.nih.gov/pubmed/35262289
http://dx.doi.org/10.1002/alz.12626
Descripción
Sumario:INTRODUCTION: We evaluated the prevalence of dementia and mild cognitive impairment (MCI) in indigenous Tsimane and Moseten, who lead a subsistence lifestyle. METHODS: Participants from population‐based samples ≥ 60 years of age (n = 623) were assessed using adapted versions of the Modified Mini‐Mental State Examination, informant interview, longitudinal cognitive testing and brain computed tomography (CT) scans. RESULTS: Tsimane exhibited five cases of dementia (among n = 435; crude prevalence = 1.2%, 95% confidence interval [CI]: 0.4, 2.7); Moseten exhibited one case (among n = 169; crude prevalence = 0.6%, 95% CI: 0.0, 3.2), all age ≥ 80 years. Age‐standardized MCI prevalence was 7.7% (95% CI: 5.2, 10.3) in Tsimane and 9.8% (95% CI: 4.9, 14.6) in Moseten. Cognitive impairment was associated with visuospatial impairments, parkinsonian symptoms, and vascular calcification in the basal ganglia. DISCUSSION: The prevalence of dementia in this cohort is among the lowest in the world. Widespread intracranial medial arterial calcifications suggest a previously unrecognized, non‐Alzheimer's disease (AD) dementia phenotype.

Ejemplares similares