Epigenetic mechanisms involved in methamphetamine addiction

Methamphetamine (METH) is an illicit psychostimulant that is widely abused. The molecular mechanism of METH addiction is complicated and still unknown. METH causes the release of the neurotransmitters including dopamine, glutamate, norepinephrine and serotonin, which activate various brain areas in...

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Autores principales: Wang, Hang, Dong, Xianghuan, Awan, Maher Un Nisa, Bai, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458865/
https://www.ncbi.nlm.nih.gov/pubmed/36091781
http://dx.doi.org/10.3389/fphar.2022.984997
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author Wang, Hang
Dong, Xianghuan
Awan, Maher Un Nisa
Bai, Jie
author_facet Wang, Hang
Dong, Xianghuan
Awan, Maher Un Nisa
Bai, Jie
author_sort Wang, Hang
collection PubMed
description Methamphetamine (METH) is an illicit psychostimulant that is widely abused. The molecular mechanism of METH addiction is complicated and still unknown. METH causes the release of the neurotransmitters including dopamine, glutamate, norepinephrine and serotonin, which activate various brain areas in the central nervous system. METH also induces synaptic plasticity and pathological memory enhancement. Epigenetics plays the important roles in regulating METH addiction. This review will briefly summarize the studies on epigenetics involved in METH addiction.
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spelling pubmed-94588652022-09-10 Epigenetic mechanisms involved in methamphetamine addiction Wang, Hang Dong, Xianghuan Awan, Maher Un Nisa Bai, Jie Front Pharmacol Pharmacology Methamphetamine (METH) is an illicit psychostimulant that is widely abused. The molecular mechanism of METH addiction is complicated and still unknown. METH causes the release of the neurotransmitters including dopamine, glutamate, norepinephrine and serotonin, which activate various brain areas in the central nervous system. METH also induces synaptic plasticity and pathological memory enhancement. Epigenetics plays the important roles in regulating METH addiction. This review will briefly summarize the studies on epigenetics involved in METH addiction. Frontiers Media S.A. 2022-08-26 /pmc/articles/PMC9458865/ /pubmed/36091781 http://dx.doi.org/10.3389/fphar.2022.984997 Text en Copyright © 2022 Wang, Dong, Awan and Bai. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Wang, Hang
Dong, Xianghuan
Awan, Maher Un Nisa
Bai, Jie
Epigenetic mechanisms involved in methamphetamine addiction
title Epigenetic mechanisms involved in methamphetamine addiction
title_full Epigenetic mechanisms involved in methamphetamine addiction
title_fullStr Epigenetic mechanisms involved in methamphetamine addiction
title_full_unstemmed Epigenetic mechanisms involved in methamphetamine addiction
title_short Epigenetic mechanisms involved in methamphetamine addiction
title_sort epigenetic mechanisms involved in methamphetamine addiction
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458865/
https://www.ncbi.nlm.nih.gov/pubmed/36091781
http://dx.doi.org/10.3389/fphar.2022.984997
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