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Warburg-like metabolic transformation underlies neuronal degeneration in sporadic Alzheimer’s disease
The drivers of sporadic Alzheimer’s disease (AD) remain incompletely understood. Utilizing directly converted induced neurons (iNs) from AD-patient-derived fibroblasts, we identified a metabolic switch to aerobic glycolysis in AD iNs. Pathological isoform switching of the glycolytic enzyme pyruvate...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458870/ https://www.ncbi.nlm.nih.gov/pubmed/35987203 http://dx.doi.org/10.1016/j.cmet.2022.07.014 |