Warburg-like metabolic transformation underlies neuronal degeneration in sporadic Alzheimer’s disease

The drivers of sporadic Alzheimer’s disease (AD) remain incompletely understood. Utilizing directly converted induced neurons (iNs) from AD-patient-derived fibroblasts, we identified a metabolic switch to aerobic glycolysis in AD iNs. Pathological isoform switching of the glycolytic enzyme pyruvate...

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Detalles Bibliográficos
Autores principales: Traxler, Larissa, Herdy, Joseph R., Stefanoni, Davide, Eichhorner, Sophie, Pelucchi, Silvia, Szücs, Attila, Santagostino, Alice, Kim, Yongsung, Agarwal, Ravi K., Schlachetzki, Johannes C.M., Glass, Christopher K., Lagerwall, Jessica, Galasko, Douglas, Gage, Fred H., D’Alessandro, Angelo, Mertens, Jerome
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458870/
https://www.ncbi.nlm.nih.gov/pubmed/35987203
http://dx.doi.org/10.1016/j.cmet.2022.07.014

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