The roles and mechanisms of epigenetic regulation in pathological myocardial remodeling

Pathological myocardial remodeling was still one of the leading causes of death worldwide with an unmet therapeutic need. A growing number of researchers have addressed the role of epigenome changes in cardiovascular diseases, paving the way for the clinical application of novel cardiovascular-relat...

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Autores principales: Zhao, Kun, Mao, Yukang, Li, Yansong, Yang, Chuanxi, Wang, Kai, Zhang, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458904/
https://www.ncbi.nlm.nih.gov/pubmed/36093141
http://dx.doi.org/10.3389/fcvm.2022.952949
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author Zhao, Kun
Mao, Yukang
Li, Yansong
Yang, Chuanxi
Wang, Kai
Zhang, Jing
author_facet Zhao, Kun
Mao, Yukang
Li, Yansong
Yang, Chuanxi
Wang, Kai
Zhang, Jing
author_sort Zhao, Kun
collection PubMed
description Pathological myocardial remodeling was still one of the leading causes of death worldwide with an unmet therapeutic need. A growing number of researchers have addressed the role of epigenome changes in cardiovascular diseases, paving the way for the clinical application of novel cardiovascular-related epigenetic targets in the future. In this review, we summarized the emerged advances of epigenetic regulation, including DNA methylation, Histone posttranslational modification, Adenosine disodium triphosphate (ATP)-dependent chromatin remodeling, Non-coding RNA, and RNA modification, in pathological myocardial remodeling. Also, we provided an overview of the mechanisms that potentially involve the participation of these epigenetic regulation.
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spelling pubmed-94589042022-09-10 The roles and mechanisms of epigenetic regulation in pathological myocardial remodeling Zhao, Kun Mao, Yukang Li, Yansong Yang, Chuanxi Wang, Kai Zhang, Jing Front Cardiovasc Med Cardiovascular Medicine Pathological myocardial remodeling was still one of the leading causes of death worldwide with an unmet therapeutic need. A growing number of researchers have addressed the role of epigenome changes in cardiovascular diseases, paving the way for the clinical application of novel cardiovascular-related epigenetic targets in the future. In this review, we summarized the emerged advances of epigenetic regulation, including DNA methylation, Histone posttranslational modification, Adenosine disodium triphosphate (ATP)-dependent chromatin remodeling, Non-coding RNA, and RNA modification, in pathological myocardial remodeling. Also, we provided an overview of the mechanisms that potentially involve the participation of these epigenetic regulation. Frontiers Media S.A. 2022-08-26 /pmc/articles/PMC9458904/ /pubmed/36093141 http://dx.doi.org/10.3389/fcvm.2022.952949 Text en Copyright © 2022 Zhao, Mao, Li, Yang, Wang and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Zhao, Kun
Mao, Yukang
Li, Yansong
Yang, Chuanxi
Wang, Kai
Zhang, Jing
The roles and mechanisms of epigenetic regulation in pathological myocardial remodeling
title The roles and mechanisms of epigenetic regulation in pathological myocardial remodeling
title_full The roles and mechanisms of epigenetic regulation in pathological myocardial remodeling
title_fullStr The roles and mechanisms of epigenetic regulation in pathological myocardial remodeling
title_full_unstemmed The roles and mechanisms of epigenetic regulation in pathological myocardial remodeling
title_short The roles and mechanisms of epigenetic regulation in pathological myocardial remodeling
title_sort roles and mechanisms of epigenetic regulation in pathological myocardial remodeling
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458904/
https://www.ncbi.nlm.nih.gov/pubmed/36093141
http://dx.doi.org/10.3389/fcvm.2022.952949
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