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Role of histone modification in the occurrence and development of osteoporosis

Osteoporosis is a systemic degenerative bone disease characterized by low bone mass and damage to bone microarchitecture, which increases bone fragility and susceptibility to fracture. The risk of osteoporosis increases with age; with the aging of the global population, osteoporosis is becoming more...

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Autores principales: Sun, Pan, Huang, Tingrui, Huang, Chen, Wang, Yongjun, Tang, Dezhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458911/
https://www.ncbi.nlm.nih.gov/pubmed/36093077
http://dx.doi.org/10.3389/fendo.2022.964103
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author Sun, Pan
Huang, Tingrui
Huang, Chen
Wang, Yongjun
Tang, Dezhi
author_facet Sun, Pan
Huang, Tingrui
Huang, Chen
Wang, Yongjun
Tang, Dezhi
author_sort Sun, Pan
collection PubMed
description Osteoporosis is a systemic degenerative bone disease characterized by low bone mass and damage to bone microarchitecture, which increases bone fragility and susceptibility to fracture. The risk of osteoporosis increases with age; with the aging of the global population, osteoporosis is becoming more prevalent, adding to the societal healthcare burden. Histone modifications such as methylation, acetylation, ubiquitination, and ADP-ribosylation are closely related to the occurrence and development of osteoporosis. This article reviews recent studies on the role of histone modifications in osteoporosis. The existing evidence indicates that therapeutic targeting of these modifications to promote osteogenic differentiation and bone formation may be an effective treatment for this disease.
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spelling pubmed-94589112022-09-10 Role of histone modification in the occurrence and development of osteoporosis Sun, Pan Huang, Tingrui Huang, Chen Wang, Yongjun Tang, Dezhi Front Endocrinol (Lausanne) Endocrinology Osteoporosis is a systemic degenerative bone disease characterized by low bone mass and damage to bone microarchitecture, which increases bone fragility and susceptibility to fracture. The risk of osteoporosis increases with age; with the aging of the global population, osteoporosis is becoming more prevalent, adding to the societal healthcare burden. Histone modifications such as methylation, acetylation, ubiquitination, and ADP-ribosylation are closely related to the occurrence and development of osteoporosis. This article reviews recent studies on the role of histone modifications in osteoporosis. The existing evidence indicates that therapeutic targeting of these modifications to promote osteogenic differentiation and bone formation may be an effective treatment for this disease. Frontiers Media S.A. 2022-08-26 /pmc/articles/PMC9458911/ /pubmed/36093077 http://dx.doi.org/10.3389/fendo.2022.964103 Text en Copyright © 2022 Sun, Huang, Huang, Wang and Tang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Sun, Pan
Huang, Tingrui
Huang, Chen
Wang, Yongjun
Tang, Dezhi
Role of histone modification in the occurrence and development of osteoporosis
title Role of histone modification in the occurrence and development of osteoporosis
title_full Role of histone modification in the occurrence and development of osteoporosis
title_fullStr Role of histone modification in the occurrence and development of osteoporosis
title_full_unstemmed Role of histone modification in the occurrence and development of osteoporosis
title_short Role of histone modification in the occurrence and development of osteoporosis
title_sort role of histone modification in the occurrence and development of osteoporosis
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458911/
https://www.ncbi.nlm.nih.gov/pubmed/36093077
http://dx.doi.org/10.3389/fendo.2022.964103
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