Analysis of lymph node spread and its prognostic significance in ampullary adenocarcinoma: A retrospective study

BACKGROUND: Nodal status is a vital prognostic factor for ampullary adenocarcinoma. This study was designed to evaluate the clinical significance of the positive nodes in this disease. METHODS: Data from 110 patients who underwent curative pancreatoduodenectomy for ampullary adenocarcinoma between J...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Zheng-Yun, Guan, Jiao, Wang, Xin-Ping, Hao, Di-Si, Zhou, Zun-Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Surgery
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458928/
https://www.ncbi.nlm.nih.gov/pubmed/36090320
http://dx.doi.org/10.3389/fsurg.2022.901615
Descripción
Sumario:BACKGROUND: Nodal status is a vital prognostic factor for ampullary adenocarcinoma. This study was designed to evaluate the clinical significance of the positive nodes in this disease. METHODS: Data from 110 patients who underwent curative pancreatoduodenectomy for ampullary adenocarcinoma between January 2007 and December 2018 were retrospectively collected and analyzed. RESULTS: The median number of lymph nodes per patient was 32 (20–46). Metastatic lymph nodes were found in 84 (76.4%) patients. In patients with positive nodules, the most commonly involved nodes were the #13 (80.1%) and #17 (78.6%) nodes, followed by #12 (69.0%) and #8 nodes (57.1%). Patients with 3–4 positive nodes among #13, #17, #12, and #8 had lower survival rates than those with 0 or 1–2 nodes. CONCLUSION: Ampullary adenocarcinoma commonly spreads to #13, #17, #12, and #8 lymph nodes. These nodes affected the patients' survival rates dramatically.

Ejemplares similares