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The relationship between the number of stenotic coronary arteries and the gut microbiome in coronary heart disease patients

An increasing number of studies have shown that the gut microbiome plays an important role in the development of coronary heart disease (CHD). However, there are no clear studies on the relationship between the gut microbiome and the number of stenotic coronary arteries. To clarify whether the gut m...

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Autores principales: Yu, Hao, Li, Le, Deng, Yu, Zhang, Guolan, Jiang, Mimi, Huang, He, Li, Cheng, Lv, Zhiyu, Zhou, Yingshun, Liu, Xing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458979/
https://www.ncbi.nlm.nih.gov/pubmed/36093192
http://dx.doi.org/10.3389/fcimb.2022.903828
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author Yu, Hao
Li, Le
Deng, Yu
Zhang, Guolan
Jiang, Mimi
Huang, He
Li, Cheng
Lv, Zhiyu
Zhou, Yingshun
Liu, Xing
author_facet Yu, Hao
Li, Le
Deng, Yu
Zhang, Guolan
Jiang, Mimi
Huang, He
Li, Cheng
Lv, Zhiyu
Zhou, Yingshun
Liu, Xing
author_sort Yu, Hao
collection PubMed
description An increasing number of studies have shown that the gut microbiome plays an important role in the development of coronary heart disease (CHD). However, there are no clear studies on the relationship between the gut microbiome and the number of stenotic coronary arteries. To clarify whether the gut microbiome is associated with the number of stenotic coronary arteries in CHD, we performed the 16S rRNA gene sequencing for the V3-V4 region in the gut microbiota from 9 healthy controls (C) and 36 CHD patients, which including 25 CHD patients with multivessel (MV) lesion and 11 CHD patients with single-vessel (SV) lesion. It showed that the abundance of the genus Escherichia-Shigella was significantly increased in the MV and SV groups compared with C group, while the abundance of the genera Subdoligranulum and Collinsella was significantly decreased. Biomarkers based on three gut microbiotas (Escherichia-Shigella, Subdoligranulum, and Collinsella) and three plasma metabolites(left atrial diameter (LA), low density lipoprotein (LDL), and total bile acids (TBA)) were able to distinguish CHD patients with different numbers of stenotic coronary arteries. Functional prediction of the gut microbiome was performed based on the Kyoto Encyclopedia of Genes and Genomes (KEGG) database. The results showed that the gut microbial function of MV and SV group patients was richer than C group in betaine biosynthesis and unsaturated fatty acid biosynthesis, in the contrast less than C group in sphingolipid metabolism and primary bile acid biosynthesis. In summary, our study showed that the composition and function of the gut microbiome changed significantly from healthy controls to CHD patients with different numbers of coronary lesions.
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spelling pubmed-94589792022-09-10 The relationship between the number of stenotic coronary arteries and the gut microbiome in coronary heart disease patients Yu, Hao Li, Le Deng, Yu Zhang, Guolan Jiang, Mimi Huang, He Li, Cheng Lv, Zhiyu Zhou, Yingshun Liu, Xing Front Cell Infect Microbiol Cellular and Infection Microbiology An increasing number of studies have shown that the gut microbiome plays an important role in the development of coronary heart disease (CHD). However, there are no clear studies on the relationship between the gut microbiome and the number of stenotic coronary arteries. To clarify whether the gut microbiome is associated with the number of stenotic coronary arteries in CHD, we performed the 16S rRNA gene sequencing for the V3-V4 region in the gut microbiota from 9 healthy controls (C) and 36 CHD patients, which including 25 CHD patients with multivessel (MV) lesion and 11 CHD patients with single-vessel (SV) lesion. It showed that the abundance of the genus Escherichia-Shigella was significantly increased in the MV and SV groups compared with C group, while the abundance of the genera Subdoligranulum and Collinsella was significantly decreased. Biomarkers based on three gut microbiotas (Escherichia-Shigella, Subdoligranulum, and Collinsella) and three plasma metabolites(left atrial diameter (LA), low density lipoprotein (LDL), and total bile acids (TBA)) were able to distinguish CHD patients with different numbers of stenotic coronary arteries. Functional prediction of the gut microbiome was performed based on the Kyoto Encyclopedia of Genes and Genomes (KEGG) database. The results showed that the gut microbial function of MV and SV group patients was richer than C group in betaine biosynthesis and unsaturated fatty acid biosynthesis, in the contrast less than C group in sphingolipid metabolism and primary bile acid biosynthesis. In summary, our study showed that the composition and function of the gut microbiome changed significantly from healthy controls to CHD patients with different numbers of coronary lesions. Frontiers Media S.A. 2022-08-26 /pmc/articles/PMC9458979/ /pubmed/36093192 http://dx.doi.org/10.3389/fcimb.2022.903828 Text en Copyright © 2022 Yu, Li, Deng, Zhang, Jiang, Huang, Li, Lv, Zhou and Liu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Yu, Hao
Li, Le
Deng, Yu
Zhang, Guolan
Jiang, Mimi
Huang, He
Li, Cheng
Lv, Zhiyu
Zhou, Yingshun
Liu, Xing
The relationship between the number of stenotic coronary arteries and the gut microbiome in coronary heart disease patients
title The relationship between the number of stenotic coronary arteries and the gut microbiome in coronary heart disease patients
title_full The relationship between the number of stenotic coronary arteries and the gut microbiome in coronary heart disease patients
title_fullStr The relationship between the number of stenotic coronary arteries and the gut microbiome in coronary heart disease patients
title_full_unstemmed The relationship between the number of stenotic coronary arteries and the gut microbiome in coronary heart disease patients
title_short The relationship between the number of stenotic coronary arteries and the gut microbiome in coronary heart disease patients
title_sort relationship between the number of stenotic coronary arteries and the gut microbiome in coronary heart disease patients
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458979/
https://www.ncbi.nlm.nih.gov/pubmed/36093192
http://dx.doi.org/10.3389/fcimb.2022.903828
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