Deficiency of the bZIP transcription factors Mafg and Mafk causes misexpression of genes in distinct pathways and results in lens embryonic developmental defects

Deficiency of the small Maf proteins Mafg and Mafk cause multiple defects, namely, progressive neuronal degeneration, cataract, thrombocytopenia and mid-gestational/perinatal lethality. Previous data shows Mafg (−/−):Mafk (+/-) compound knockout (KO) mice exhibit cataracts age 4-months onward. Strik...

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Detalles Bibliográficos
Autores principales: Patel, Shaili D., Anand, Deepti, Motohashi, Hozumi, Katsuoka, Fumiki, Yamamoto, Masayuki, Lachke, Salil A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9459095/
https://www.ncbi.nlm.nih.gov/pubmed/36092713
http://dx.doi.org/10.3389/fcell.2022.981893

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