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Association between squamous cell carcinoma antigen level and EGFR mutation status in Chinese lung adenocarcinoma patients

BACKGROUND: To investigate the association between squamous cell carcinoma antigen (SCCAg) level and epidermal growth factor receptor (EGFR) mutation status in Chinese lung adenocarcinoma patients. METHODS: We retrospectively analyzed 293 patients with lung adenocarcinoma, divided into EGFR mutant g...

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Autores principales: Zhang, Shuying, Gao, Jianxiong, Niu, Rong, Ye, Jiru, Ma, Jinhong, Jiang, Lijuan, Shao, Xiaonan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9459300/
https://www.ncbi.nlm.nih.gov/pubmed/35838003
http://dx.doi.org/10.1002/jcla.24613
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author Zhang, Shuying
Gao, Jianxiong
Niu, Rong
Ye, Jiru
Ma, Jinhong
Jiang, Lijuan
Shao, Xiaonan
author_facet Zhang, Shuying
Gao, Jianxiong
Niu, Rong
Ye, Jiru
Ma, Jinhong
Jiang, Lijuan
Shao, Xiaonan
author_sort Zhang, Shuying
collection PubMed
description BACKGROUND: To investigate the association between squamous cell carcinoma antigen (SCCAg) level and epidermal growth factor receptor (EGFR) mutation status in Chinese lung adenocarcinoma patients. METHODS: We retrospectively analyzed 293 patients with lung adenocarcinoma, divided into EGFR mutant group (n = 178) and EGFR wild‐type group (n = 115). The general data and laboratory parameters of the two groups were compared. We used univariable and multivariable logistic regression to analyze the association between SCCAg level and EGFR mutation. Generalized additive model was used for curve fitting, and a hierarchical binary logistic regression model was used for interaction analysis. RESULTS: Squamous cell carcinoma antigen level in the EGFR wild‐type group was significantly higher than that in the mutant group (p < 0.001). After adjusting for confounding factors, we found that elevated SCCAg was associated with a lower probability of EGFR mutation, with an OR of 0.717 (95% CI: 0.543–0.947, p = 0.019). For the tripartite SCCAg groups, the increasing trend of SCCAg was significantly associated with the decreasing probability of EGFR mutation (p for trend = 0.015), especially for Tertile 3 versus Tertile 1 (OR = 0.505; 95% CI: 0.258–0.986; p = 0.045). Curve fitting showed that there was an approximate linear negative relationship between continuous SCCAg and EGFR mutation probability (p = 0.020), which was first flattened and then decreased (p < 0.001). The association between the two was consistent among different subgroups, suggesting no interaction (all p > 0.05). CONCLUSION: There is a negative association between SCCAg level and EGFR mutation probability in Chinese lung adenocarcinoma patients.
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spelling pubmed-94593002022-09-12 Association between squamous cell carcinoma antigen level and EGFR mutation status in Chinese lung adenocarcinoma patients Zhang, Shuying Gao, Jianxiong Niu, Rong Ye, Jiru Ma, Jinhong Jiang, Lijuan Shao, Xiaonan J Clin Lab Anal Research Articles BACKGROUND: To investigate the association between squamous cell carcinoma antigen (SCCAg) level and epidermal growth factor receptor (EGFR) mutation status in Chinese lung adenocarcinoma patients. METHODS: We retrospectively analyzed 293 patients with lung adenocarcinoma, divided into EGFR mutant group (n = 178) and EGFR wild‐type group (n = 115). The general data and laboratory parameters of the two groups were compared. We used univariable and multivariable logistic regression to analyze the association between SCCAg level and EGFR mutation. Generalized additive model was used for curve fitting, and a hierarchical binary logistic regression model was used for interaction analysis. RESULTS: Squamous cell carcinoma antigen level in the EGFR wild‐type group was significantly higher than that in the mutant group (p < 0.001). After adjusting for confounding factors, we found that elevated SCCAg was associated with a lower probability of EGFR mutation, with an OR of 0.717 (95% CI: 0.543–0.947, p = 0.019). For the tripartite SCCAg groups, the increasing trend of SCCAg was significantly associated with the decreasing probability of EGFR mutation (p for trend = 0.015), especially for Tertile 3 versus Tertile 1 (OR = 0.505; 95% CI: 0.258–0.986; p = 0.045). Curve fitting showed that there was an approximate linear negative relationship between continuous SCCAg and EGFR mutation probability (p = 0.020), which was first flattened and then decreased (p < 0.001). The association between the two was consistent among different subgroups, suggesting no interaction (all p > 0.05). CONCLUSION: There is a negative association between SCCAg level and EGFR mutation probability in Chinese lung adenocarcinoma patients. John Wiley and Sons Inc. 2022-07-15 /pmc/articles/PMC9459300/ /pubmed/35838003 http://dx.doi.org/10.1002/jcla.24613 Text en © 2022 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Research Articles
Zhang, Shuying
Gao, Jianxiong
Niu, Rong
Ye, Jiru
Ma, Jinhong
Jiang, Lijuan
Shao, Xiaonan
Association between squamous cell carcinoma antigen level and EGFR mutation status in Chinese lung adenocarcinoma patients
title Association between squamous cell carcinoma antigen level and EGFR mutation status in Chinese lung adenocarcinoma patients
title_full Association between squamous cell carcinoma antigen level and EGFR mutation status in Chinese lung adenocarcinoma patients
title_fullStr Association between squamous cell carcinoma antigen level and EGFR mutation status in Chinese lung adenocarcinoma patients
title_full_unstemmed Association between squamous cell carcinoma antigen level and EGFR mutation status in Chinese lung adenocarcinoma patients
title_short Association between squamous cell carcinoma antigen level and EGFR mutation status in Chinese lung adenocarcinoma patients
title_sort association between squamous cell carcinoma antigen level and egfr mutation status in chinese lung adenocarcinoma patients
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9459300/
https://www.ncbi.nlm.nih.gov/pubmed/35838003
http://dx.doi.org/10.1002/jcla.24613
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