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Development of a novel lactate dehydrogenase A inhibitor with potent antitumor activity and immune activation

Lactate accumulation in the tumor microenvironment was shown to be closely related to tumor growth and immune escape, and suppression of lactate production by inhibiting lactate dehydrogenase A (LDHA) has been pursued as a potential novel antitumor strategy. However, only a few potent LDHA inhibitor...

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Detalles Bibliográficos
Autores principales:	Du, Mengyan, Yu, Ting, Zhan, Qinjinge, Li, Han, Zou, Yiping, Geng, Meiyu, Meng, Tao, Xie, Zuoquan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	ORIGINAL ARTICLES
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9459323/ https://www.ncbi.nlm.nih.gov/pubmed/35722994 http://dx.doi.org/10.1111/cas.15468

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