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Altered membrane properties but unchanged intrinsic excitability and spontaneous postsynaptic currents in an aged APP(swe)/PS1dE9 model of Alzheimer’s disease

Neuronal hyperexcitability in Alzheimer’s disease (AD) models is thought to either contribute to the formation of amyloid beta plaques or result from their formation. Neuronal hyperexcitability has been shown in the cerebral cortex of the widely used young APPswe/PS1dE9 mice, which have accelerated...

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Detalles Bibliográficos
Autores principales:	Ohline, Shane M., Liu, Xinhuai, Ibrahim, Mohamed F., Mockett, Bruce M., Empson, Ruth M., Abraham, Wickliffe C., Iremonger, Karl J., Jones, Peter P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cellular Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9459330/ https://www.ncbi.nlm.nih.gov/pubmed/36090787 http://dx.doi.org/10.3389/fncel.2022.958876

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