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Immune responses in COVID-19 and tuberculosis coinfection: A scoping review
BACKGROUND AND AIM: Patients with COVID-19 and tuberculosis coinfection are at an increased risk of severe disease and death. We therefore sought to evaluate the current evidence which assessed the immune response in COVID-19 and tuberculosis coinfection METHODS: We searched Pubmed/MEDLINE, EMBASE,...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9459402/ https://www.ncbi.nlm.nih.gov/pubmed/36090983 http://dx.doi.org/10.3389/fimmu.2022.992743 |
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author | Flores-Lovon, Kevin Ortiz-Saavedra, Brando Cueva-Chicaña, Luis A. Aperrigue-Lira, Shalom Montes-Madariaga, Elizbet S. Soriano-Moreno, David R. Bell, Brett Macedo, Rodney |
author_facet | Flores-Lovon, Kevin Ortiz-Saavedra, Brando Cueva-Chicaña, Luis A. Aperrigue-Lira, Shalom Montes-Madariaga, Elizbet S. Soriano-Moreno, David R. Bell, Brett Macedo, Rodney |
author_sort | Flores-Lovon, Kevin |
collection | PubMed |
description | BACKGROUND AND AIM: Patients with COVID-19 and tuberculosis coinfection are at an increased risk of severe disease and death. We therefore sought to evaluate the current evidence which assessed the immune response in COVID-19 and tuberculosis coinfection METHODS: We searched Pubmed/MEDLINE, EMBASE, Scopus, and Web of Science to identify articles published between 2020 and 2021. We included observational studies evaluating the immune response in patients with tuberculosis and COVID-19 compared to patients with COVID-19 alone. RESULTS: Four cross-sectional studies (372 participants) were identified. In patients with asymptomatic COVID-19 and latent tuberculosis (LTBI), increased cytokines, chemokines, growth factors and humoral responses were found. In addition, patients with symptomatic COVID-19 and LTBI had higher leukocytes counts and less inflammation. Regarding patients with COVID-19 and active tuberculosis (aTB), they exhibited decreased total lymphocyte counts, CD4 T cells specific against SARS-CoV-2 and responsiveness to SARS-CoV-2 antigens compared to patients with only COVID-19. CONCLUSION: Although the evidence is limited, an apparent positive immunomodulation is observed in patients with COVID-19 and LTBI. On the other hand, patients with COVID-19 and aTB present a dysregulated immune response. Longitudinal studies are needed to confirm these findings and expand knowledge. |
format | Online Article Text |
id | pubmed-9459402 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94594022022-09-10 Immune responses in COVID-19 and tuberculosis coinfection: A scoping review Flores-Lovon, Kevin Ortiz-Saavedra, Brando Cueva-Chicaña, Luis A. Aperrigue-Lira, Shalom Montes-Madariaga, Elizbet S. Soriano-Moreno, David R. Bell, Brett Macedo, Rodney Front Immunol Immunology BACKGROUND AND AIM: Patients with COVID-19 and tuberculosis coinfection are at an increased risk of severe disease and death. We therefore sought to evaluate the current evidence which assessed the immune response in COVID-19 and tuberculosis coinfection METHODS: We searched Pubmed/MEDLINE, EMBASE, Scopus, and Web of Science to identify articles published between 2020 and 2021. We included observational studies evaluating the immune response in patients with tuberculosis and COVID-19 compared to patients with COVID-19 alone. RESULTS: Four cross-sectional studies (372 participants) were identified. In patients with asymptomatic COVID-19 and latent tuberculosis (LTBI), increased cytokines, chemokines, growth factors and humoral responses were found. In addition, patients with symptomatic COVID-19 and LTBI had higher leukocytes counts and less inflammation. Regarding patients with COVID-19 and active tuberculosis (aTB), they exhibited decreased total lymphocyte counts, CD4 T cells specific against SARS-CoV-2 and responsiveness to SARS-CoV-2 antigens compared to patients with only COVID-19. CONCLUSION: Although the evidence is limited, an apparent positive immunomodulation is observed in patients with COVID-19 and LTBI. On the other hand, patients with COVID-19 and aTB present a dysregulated immune response. Longitudinal studies are needed to confirm these findings and expand knowledge. Frontiers Media S.A. 2022-08-26 /pmc/articles/PMC9459402/ /pubmed/36090983 http://dx.doi.org/10.3389/fimmu.2022.992743 Text en Copyright © 2022 Flores-Lovon, Ortiz-Saavedra, Cueva-Chicaña, Aperrigue-Lira, Montes-Madariaga, Soriano-Moreno, Bell and Macedo https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Flores-Lovon, Kevin Ortiz-Saavedra, Brando Cueva-Chicaña, Luis A. Aperrigue-Lira, Shalom Montes-Madariaga, Elizbet S. Soriano-Moreno, David R. Bell, Brett Macedo, Rodney Immune responses in COVID-19 and tuberculosis coinfection: A scoping review |
title | Immune responses in COVID-19 and tuberculosis coinfection: A scoping review |
title_full | Immune responses in COVID-19 and tuberculosis coinfection: A scoping review |
title_fullStr | Immune responses in COVID-19 and tuberculosis coinfection: A scoping review |
title_full_unstemmed | Immune responses in COVID-19 and tuberculosis coinfection: A scoping review |
title_short | Immune responses in COVID-19 and tuberculosis coinfection: A scoping review |
title_sort | immune responses in covid-19 and tuberculosis coinfection: a scoping review |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9459402/ https://www.ncbi.nlm.nih.gov/pubmed/36090983 http://dx.doi.org/10.3389/fimmu.2022.992743 |
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